SynthesisBMJ open2016
Prognostic models in acute pulmonary embolism: a systematic review and meta-analysis.
Synthesis in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613855 (Performance of Pulmonary Embolism Risk Scores for Assessment of Outcome in Computed Tomographic Pulmonary Angiography Confirmed Patients), which is not on this map. Cited by 84 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Performance of Pulmonary Embolism Risk Scores for Assessment of Outcome in Computed Tomographic Pulmonary Angiography Confirmed Patients
Who cites it
84 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Thromboembolic events in pelvic and acetabulum fractures: a systematic review of the current literature on incidence, screening, and thromboprophylaxis.International orthopaedics · 2022Pooled it
- Predictive scores for the diagnosis of Pulmonary Embolism in COVID-19: A systematic review.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Pooled it
- Comprehensive Outpatient Management of Low-Risk Pulmonary Embolism: Can Primary Care Do This? A Narrative Review.The Permanente journal · 2020Pooled it
- Predicting future self-harm or suicide in adolescents: a systematic review of risk assessment scales/tools.BMJ open · 2019Pooled it
- Prognostic role of neutrophils to lymphocytes ratio in patients with acute pulmonary embolism: a systematic review and meta-analysis of the literature.Internal and emergency medicine · 2018Pooled it
- Initiation of an emergency department discharge pathway for low-risk patients with venous thromboembolism: Factors impact real-world practice.Vascular medicine (London, England) · 2026Article
- Trends and Therapeutic Imperatives in Pulmonary Embolism Therapy.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Expanding outpatient eligibility using a narrow definition of cancer in the Pulmonary Embolism Severity Index.Research and practice in thrombosis and haemostasis · 2026Article
- Clinical and Socioeconomic Predictors of In-hospital Mortality in Acute Pulmonary Embolism: A Cross-sectional Study using the US National Inpatient Sample data.Research and practice in thrombosis and haemostasis · 2026Article
- Risk stratification in pulmonary embolism: current evidence and future directions.The Journal of cardiovascular surgery · 2026Review
- The prognostic nutritional index improves risk stratification for acute pulmonary embolism.iScience · 2026Article
- Evaluating the Predictive Value of the Endothelial Activation and Stress Index in Determining the Severity and Prognosis of Acute Pulmonary Embolism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- L-Shaped Association of 24-Hour Urine Output with 3-Month and 1-Year All-Cause Mortality in Patients with Acute Pulmonary Embolism: A Retrospective Cohort Study.Journal of atherosclerosis and thrombosis · 2025Article
- Use of Radiomics to Predict Adverse Outcomes in Patients with Pulmonary Embolism: A Scoping Review of an Unresolved Clinical Challenge.Diagnostics (Basel, Switzerland) · 2025Review
- Comparison of half-dose alteplase and LMWH in intermediate-high risk pulmonary embolism: a single-center observational study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Red cell distribution width-standard deviation to albumin ratio and mortality in acute pulmonary thromboembolism: a single-center retrospective cohort study.Thrombosis journal · 2025Article
- A predictive model for hospital death in cancer patients with acute pulmonary embolism using XGBoost machine learning and SHAP interpretation.Scientific reports · 2025Article
- Beyond a Single Marker: An Update on the Comprehensive Evaluation of Right Ventricular Dysfunction in Pulmonary Thromboembolism.Life (Basel, Switzerland) · 2025Review
- Echocardiography-Based Pulmonary Artery Pulsatility Index Correlates with Outcomes in Patients with Acute Pulmonary Embolism.Journal of clinical medicine · 2025Article
- Limitations and Future Perspectives on Pulmonary Embolism: So Far, So Good.Interventional cardiology (London, England) · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the evidence for existing prognostic models in acute pulmonary embolism (PE) and determine how valid and useful they are for predicting patient outcomes.
designSystematic review and meta-analysis. DATA SOURCES: OVID MEDLINE and EMBASE, and The Cochrane Library from inception to July 2014, and sources of grey literature. ELIGIBILITY CRITERIA: Studies aiming at constructing, validating, updating or studying the impact of prognostic models to predict all-cause death, PE-related death or venous thromboembolic events up to a 3-month follow-up in patients with an acute symptomatic PE. DATA EXTRACTION: Study characteristics and study quality using prognostic criteria. Studies were selected and data extracted by 2 reviewers. DATA ANALYSIS: Summary estimates (95% CI) for proportion of risk groups and event rates within risk groups, and accuracy.
resultsWe included 71 studies (44,298 patients). Among them, 17 were model construction studies specific to PE prognosis. The most validated models were the PE Severity Index (PESI) and its simplified version (sPESI). The overall 30-day mortality rate was 2.3% (1.7% to 2.9%) in the low-risk group and 11.4% (9.9% to 13.1%) in the high-risk group for PESI (9 studies), and 1.5% (0.9% to 2.5%) in the low-risk group and 10.7% (8.8% to12.9%) in the high-risk group for sPESI (11 studies). PESI has proved clinically useful in an impact study. Shifting the cut-off or using novel and updated models specifically developed for normotensive PE improves the ability for identifying patients at lower risk for early death or adverse outcome (0.5-1%) and those at higher risk (up to 20-29% of event rate).
conclusionsWe provide evidence-based information about the validity and utility of the existing prognostic models in acute PE that may be helpful for identifying patients at low risk. Novel models seem attractive for the high-risk normotensive PE but need to be externally validated then be assessed in impact studies.
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