Evidence map›Paper›PMID 27130045›Full record

ReviewBMC neurology2016

Two endogenous retroviral loci appear to contribute to Multiple Sclerosis.

Bjørn A Nexø, Sara B Jensen, Kari K Nissen, Bettina Hansen, Magdalena J Laska

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bjørn A NexøAarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark. nexo@biomed.au.dk.
Sara B JensenAarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark.
Kari K NissenAarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark.
Bettina HansenAarhus University, Biomedicine, Bartholin Building, Wilhelm Meyers Alle 4, DK-8000, Aarhus C, Denmark.
Magdalena J LaskaDepartment of Clinical Medicine, Aarhus University, DK-8000, Aarhus C, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTwo endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).

resultsThe two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.

conclusionWe formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

Indexed as

Diabetes Mellitus, Type 1Endogenous RetrovirusesHumansMultiple SclerosisEndogenous retroviral lociMultiple sclerosisRheumatoid arthritisSynergy of virusesType 1 Diabetes

Identifiers

PMID27130045
PMCPMC4851805

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.