Evidence map›Paper›PMID 27129979›Full record

Trial reportJournal of gastroenterology2017

Factors associated with poor therapeutic response in outpatients with irritable bowel syndrome: a multicenter study in Japan.

Eiji Yamada, Seishi Tsunoda, Tsuyoshi Abe, Eri Uchida, Hiromichi Teraoka, Seitaro Watanabe, Ichiro Kawana, Masataka Tagri, Noriomi Hosaka, Kazuki Nagai and 2 more

Abstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Sex-Gender Differences in Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Eiji YamadaGastroenterology Division, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.
Seishi TsunodaTsunoda Iin, Yokohama, Japan.
Tsuyoshi AbeAbe Clinic, Sagamihara, Japan.
Eri UchidaGastroenterology Division, Chigasaki Municipal Hospital, Chigasaki, Japan.
Hiromichi TeraokaTeraoka Clinic, Yokohama, Japan.
Seitaro WatanabeGastroenterology Division, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.
Ichiro KawanaGastroenterology Division, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.
Masataka TagriDepartment of Biostatistics and Epidemiology, Yokohama City University School of Medicine, Yokohama, Japan.
Noriomi HosakaHikari Clinic, Yokohama, Japan.
Kazuki NagaiNagai Clinic, Yokohama, Japan.
Haruo NishinoMatsushima Clinic, Yokohama, Japan.
Atsushi NakajimaDepartment of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama, 236-0004, Japan. nakajima-tky@umin.ac.jp.
Yokohama City University · JPNational Sagamihara Hospital · JPTaoka Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome patients with irritable bowel syndrome (IBS) show poor response to treatment. However, risk factors associated with poor therapeutic response have not been determined.

methodsThis multicenter trial evaluated consecutive outpatients with IBS undergoing treatment for more than 1 month. Mental health status and physical function were evaluated using the Japanese version of the SF-8. Therapeutic response was evaluated using the IBS severity index-Japanese version (IBS-SIJ). Patients with IBS-SIJ scores ≥175 were defined as poor responders to treatment, whereas those with IBS-SIJ scores <175 were defined as good responders. The demographic and clinical characteristics of these two groups, along with medications, were compared.

resultsThe study enrolled 131 participants, 75 with IBS-SIJ scores ≥175-56 with IBS-SIJ scores <175. Multiple logistic regression analysis showed that female sex [odds ratio (OR) 2.67, 95 % confidence interval (CI) 1.19-5.97, p = 0.0167] and mental component summary (MCS) of the SF-8 <40 (OR 2.58, 95 % CI 1.12-5.97, p = 0.0263) were independent risk factors for poor therapeutic response in patients with IBS.

conclusionsLower MCS and female sex were risk factors for poor therapeutic response in patients with IBS. Ascertaining the mechanisms by which lower MCS and female sex are associated with poor therapeutic response in IBS may help design better treatments (Trial registration number: UMIN000016804).

Indexed as

AdolescentAdultAgedAged, 80 and overAmbulatory CareFemaleGastrointestinal AgentsHumansIrritable Bowel SyndromeJapanMaleMental HealthMiddle AgedPrognosisPsychometricsQuality of LifeGastrointestinal AgentsIrritable bowel syndromeMental healthPoor therapeutic response

Identifiers

PMID27129979
OpenAlexW2343595514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.