Evidence map›Paper›PMID 27129769›Full record

ArticleThe Journal of biological chemistry2016

Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.

Fred D Mast, Arvind Jamakhandi, Ramsey A Saleem, David J Dilworth, Richard S Rogers, Richard A Rachubinski, John D Aitchison

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  4. Synthetic and systems biotechnology · 2025
    Article
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  7. Article
  8. Review
  9. Article
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  13. Review
  14. Article
  15. Article
  16. Structure-function analysis of the ER-peroxisome contact site protein Pex32.Frontiers in cell and developmental biology · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fred D MastFrom the Center for Infectious Disease Research and Institute for Systems Biology, Seattle, Washington 98109 and.ORCID 0000-0002-2177-6647
Arvind JamakhandiFrom the Center for Infectious Disease Research and Institute for Systems Biology, Seattle, Washington 98109 and.
Ramsey A SaleemFrom the Center for Infectious Disease Research and Institute for Systems Biology, Seattle, Washington 98109 and.
David J DilworthFrom the Center for Infectious Disease Research and Institute for Systems Biology, Seattle, Washington 98109 and.
Richard S RogersFrom the Center for Infectious Disease Research and Institute for Systems Biology, Seattle, Washington 98109 and.
Richard A Rachubinskithe Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
John D AitchisonFrom the Center for Infectious Disease Research and Institute for Systems Biology, Seattle, Washington 98109 and john.aitchison@CIDResearch.org.

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2006 to 2016
$30.6M
TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
CIHR 143289NIGMS NIH HHS P41 GM109824NIGMS NIH HHS P50 GM076547
6 · The paper itself

Abstract

Peroxisome proliferation occurs by at least two routes, division of existing peroxisomes and de novo biogenesis from the endoplasmic reticulum (ER). The proteins and molecular mechanisms governing peroxisome emergence from the ER are poorly characterized. In this study, we report that two integral membrane peroxins (proteins required for peroxisome biogenesis) in Saccharomyces cerevisiae, Pex29 and Pex30, reside in distinct regions of the ER and associate with Rtn1 and Yop1, reticulon family members that contribute to ER morphology, to govern peroxisome emergence from the ER. In vivo and in vitro analyses reveal that peroxisome proliferation is therefore not restricted to the peroxisome but begins at the level of the ER.

Indexed as

Endoplasmic ReticulumMembrane ProteinsMembrane Transport ProteinsPeroxisomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMembrane ProteinsMembrane Transport ProteinsPEX29 protein, S cerevisiaePex30 protein, S cerevisiaeRtn1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsYOP1 protein, S cerevisiaeendoplasmic reticulum (ER)microscopyperoxinperoxisomeperoxisomesreticulonsubcellular fractionationsubcellular organelleyeast

Identifiers

PMID27129769
PMCPMC4957030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.