ArticleMolecular nutrition & food research2017
Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups.
Article in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A Systematic Review to Reassess the Formula for Early Life Growth.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- Investigation of VGLL3 and sub-target genes in the aetiology of paediatric acute appendicitis: a prospective case-control study.Pediatric surgery international · 2023Article
- Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.European journal of nutrition · 2023Article
- Early life adverse exposures in irritable bowel syndrome: new insights and opportunities.Frontiers in pediatrics · 2023Review
- Article
- Impact of Maternal Obesity on Liver Disease in the Offspring: A Comprehensive Transcriptomic Analysis and Confirmation of Results in a Murine Model.Biomedicines · 2022Article
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspringFrontiers in nutrition · 2022Article
- Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders.Nutrients · 2021Review
- Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity.International journal of environmental research and public health · 2020Review
- Article
- Emerging roles of bile acids in mucosal immunity and inflammation.Mucosal immunology · 2019Review
- Genetic association and differential expression of PITX2 with acute appendicitis.Human genetics · 2019Article
- Milk lipid regulation at the maternal-offspring interface.Seminars in cell & developmental biology · 2018Review
- Maternal High Fat Diet Alters Gut Microbiota of Offspring and Exacerbates DSS-Induced Colitis in Adulthood.Frontiers in immunology · 2018Article
- Multi-Level Integration of Environmentally Perturbed Internal Phenotypes Reveals Key Points of Connectivity between Them.Frontiers in physiology · 2017Article
- Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups.Molecular nutrition & food research · 2017Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
scopeThe long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident. The effects of maternal nutrition on the developing intestine are still underexplored. METHODS AND
resultsIn this study, we observed (1) altered microbiota composition of the colonic luminal content, and (2) differential gene expression in the intestinal wall in 2-week-old mouse pups born from dams exposed to a Western-style (WS) diet during the perinatal period. A sexually dimorphic effect was found for the differentially expressed genes in the offspring of WS diet-exposed dams but no differences between male and female pups were found for the microbiota composition. Integrative analysis of the microbiota and gene expression data revealed that the maternal WS diet independently affected gene expression and microbiota composition. However, the abundance of bacterial families not affected by the WS diet (Bacteroidaceae, Porphyromonadaceae, and Lachnospiraceae) correlated with the expression of genes playing a key role in intestinal development and functioning (e.g. Pitx2 and Ace2).
conclusionOur data reveal that maternal consumption of a WS diet during the perinatal period alters both gene expression and microbiota composition in the intestinal tract of 2-week-old offspring.
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