ArticleClinical rheumatology2016
Delayed wound healing and postoperative surgical site infections in patients with rheumatoid arthritis treated with or without biological disease-modifying antirheumatic drugs.
Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Perioperative Management of Antirheumatic Medications in Adults with Rheumatoid Arthritis Undergoing Arthroplasty and Other Orthopedic Procedures: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Effect of tumour necrosis factor-a inhibitors exposure on surgical site infections in rheumatoid arthritis patients undergoing elective orthopaedic surgery: A meta-analysis.International wound journal · 2024Pooled it
- A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Effect of short-term methotrexate discontinuation on rheumatoid arthritis disease activity: post-hoc analysis of two randomized trials.Clinical rheumatology · 2020Trial
- Clinical Consensus Statement: Perioperative Management of Prothrombotics, Antiplatelets, Anticoagulants, DMARDs and Biologics in Elective Podiatric Surgery.Journal of foot and ankle research · 2026Article
- Immune dysregulation and postoperative wound complications in systemic autoimmune rheumatic diseases: toward disease-specific risk stratification.Frontiers in immunology · 2026Article
- Assessing Patient Understanding and Adherence to Preoperative Medication Advice Provided in Pre-Admission Clinic.Healthcare (Basel, Switzerland) · 2025Article
- Development of biomedical hydrogels for rheumatoid arthritis treatment.Asian journal of pharmaceutical sciences · 2024Review
- Soft-tissue coverage for wound complications following total elbow arthroplasty.Clinics in shoulder and elbow · 2021Article
- Modified Anterolateral Approach for Total Ankle Arthroplasty.Foot & ankle orthopaedics · 2021Article
- Anti-rheumatic treatment and prosthetic joint infection: an observational study in 494 elective hip and knee arthroplasties.BMC musculoskeletal disorders · 2020Observational
- Tocilizumab Was Effective in Repairing the Large Geode in a Patient with Rheumatoid Arthritis.Case reports in rheumatology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological disease-modifying antirheumatic drugs (bDMARDs) have become more popular for treating rheumatoid arthritis (RA). Whether or not bDMARDs increase the postoperative risk of surgical site infection (SSI) has remained controversial. We aimed to clarify the effects of bDMARDs on the outcomes of elective orthopedic surgery. We used multivariate logistic regression analysis to analyze risk factors for SSI and delayed wound healing among 227 patients with RA (mean age, 65.0 years; disease duration, 16.9 years) after 332 elective orthopedic surgeries. We also attempted to evaluate the effects of individual medications on infection. Rates of bDMARD and conventional synthetic DMARD (csDMARD) administration were 30.4 and 91.0 %, respectively. Risk factors for SSI were advanced age (odds ratio [OR], 1.11; P = 0.045), prolonged surgery (OR, 1.02; P = 0.03), and preoperative white blood cell count >10,000/μL (OR, 3.66; P = 0.003). Those for delayed wound healing were advanced age (OR, 1.16; P = 0.001), prolonged surgery (OR, 1.02; P = 0.007), preoperative white blood cell count >10,000/μL (OR, 4.56; P = 0.02), and foot surgery (OR, 6.60; P = 0.001). Risk factors for SSI and medications did not significantly differ. No DMARDs were risk factors for any outcome examined. Biological DMARDs were not risk factors for postoperative SSI. Foot surgery was a risk factor for delayed wound healing.
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