ArticleDigestive diseases and sciences2016
Factors Associated with Upper Gastrointestinal Cancer Occurrence After Endoscopy that Did Not Diagnose Cancer.
Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy.Surgical endoscopy · 2021Trial
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- Missed duodenal tumors at upper endoscopy: a five year retrospective cohort study at West China hospital (2019-2023).BMC gastroenterology · 2026Article
- Development of a national root cause analysis system for post-endoscopy upper gastrointestinal cancer.Endoscopy international open · 2026Article
- Article
- Post-endoscopy esophageal adenocarcinoma and root cause analysis in Auckland, New Zealand.Endoscopy international open · 2025Article
- Esophageal cancers missed at upper endoscopy in Central Norway 2004 to 2021 - A population-based study.BMC gastroenterology · 2024Article
- Post-Endoscopy Upper Gastrointestinal Cancer Rate in a Tertiary Referral Centre: An Australian Data Linkage Analysis.Journal of gastrointestinal cancer · 2023Article
- Article
- Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016-A Population-Based Study.Cancers · 2021Article
- Rate of missed oesophageal cancer at routine endoscopy and survival outcomes: A multicentric cohort study.United European gastroenterology journal · 2019Article
- Reassessing the value of gastroscopy for the investigation of dyspepsia.Frontline gastroenterology · 2018Article
- The National Oesophagogastric Cancer Awareness Campaign: a locality outcome analysis from County Durham.Frontline gastroenterology · 2017Article
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Authors and funding
5 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsUp to 14 % of upper gastrointestinal cancer (UGIC) subjects underwent esophago-gastro-duodenoscopy (EGD) in the preceding 3 years, which did not detect UGIC. The frequency of such events and associated risk factors was evaluated.
methodsUGIC subjects were identified from a UK primary care database. Post-EGD upper gastrointestinal cancers (PEUGIC) cases were subjects undergoing EGD 12-36 months prior to UGIC diagnosis. Controls had not undergone EGD during the same period. Logistic regression analysis examined associations with PEUGIC.
results4249 gastric cancer (GC) subjects (44.8 %) and 5238 esophageal cancer (EC) subjects (55.2 %) were analyzed. There were 633 (6.7 %) PEUGIC subjects [279 EC and 354 GC]. Multivariate analysis revealed that younger age [OR 1.02, (95 % CI 1.01-1.03), p < 0.0001], female gender [1.39 (1.17-1.64), p < 0.0001], increasing comorbidity [1.35 (1.13-1.61), p < 0.0001], and greater deprivation [1.31 (1.09-1.59), p = 0.005] were associated with PEUGIC. Alarm symptoms on presentation [0.32 (0.26-0.40), p < 0.0001] were less likely to be associated with PEUGIC. GC was more likely to be associated with PEUGIC than EC [1.33 (1.13-1.58), p = 0.001]. PEUGIC EGDs reported findings associated with UGIC (stricture or ulceration) in 8.3 % of cases, and only 60.9 % had a follow-up EGD within 90 days. PEUGIC rate declined from 7.9 to 2.7 % for EC and 9.0-6.5 % for GC during the study period.
conclusionsPEUGIC occurs in 6.7 % of UGIC. PEUGIC was associated with GC, younger age, female gender, increasing comorbidity and deprivation, and a lack of alarm symptoms.
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