ArticleDigestive diseases and sciences2016
Breath Methane Levels Are Increased Among Patients with Diverticulosis.
Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Intestinal gases as markers to study the diet-gut microbiota-host metabolism axis in humans and their relationship to metabolic health.Gut microbes · 2026Review
- Human Milk Archaea Associated with Neonatal Gut Colonization and Its Co-Occurrence with Bacteria.Microorganisms · 2025Article
- The relationship between small intestinal bacterial overgrowth and constipation in children - a comprehensive review.Frontiers in cellular and infection microbiology · 2024Review
- Modification of baseline status to improve breath tests performance.Scientific reports · 2022Article
- Bacteria and Methanogens in the Human Microbiome: a Review of Syntrophic Interactions.Microbial ecology · 2022Review
- Lactose Intolerance: What Your Breath Can Tell You.Diagnostics (Basel, Switzerland) · 2020Review
- Methanogenic Archaea: Emerging Partners in the Field of Allergic Diseases.Clinical reviews in allergy & immunology · 2019Review
- Methanogens as emerging pathogens in anaerobic abscesses.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Increasing Diverticulosis in an Aging Population: A Colonoscopy-Based Study of 5-Year Trends in 26 463 Patients in Northern China.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China.Scientific reports · 2018Article
- Logical hypothesis: Low FODMAP diet to prevent diverticulitis.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDiverticulosis and its complications are important healthcare problems in the USA and throughout the Western world. While mechanisms as to how diverticulosis occurs have partially been explored, few studies examined the relationship between colonic gases such as methane and diverticulosis in humans.
aimThis study aimed to demonstrate a significant relationship between methanogenic Archaea and development of diverticulosis.
methodsSubjects who consecutively underwent hydrogen breath test at Rush University Medical Center between 2003 and 2010 were identified retrospectively through a database. Medical records were reviewed for presence of a colonoscopy report. Two hundred and sixty-four subjects were identified who had both a breath methane level measurement and a colonoscopy result. Additional demographic and clinical data were obtained with chart review.
resultsMean breath methane levels were higher in subjects with diverticulosis compared to those without diverticulosis (7.89 vs. 4.94 ppm, p = 0.04). Methane producers (defined as those with baseline fasting breath methane level >5 ppm) were more frequent among subjects with diverticulosis compared to those without diverticulosis (50.9 vs. 34 %, p = 0.0025). When adjusted for confounders, breath methane levels and age were the two independent predictors of diverticulosis on colonoscopy with logistic regression modeling.
conclusionsMethanogenesis is associated with the presence of diverticulosis. Further studies are needed to confirm our findings and prospectively evaluate a possible etiological role of methanogenesis and methanogenic archaea in diverticulosis.
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Registered trials
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