ArticleBiological psychiatry2017
Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- Article
- Development of catecholaminergic neurons of Otp-lineage in the medial extended amygdala and related forebrain centers.Frontiers in neuroanatomy · 2025Article
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Transcriptomic analysis of paternal behaviors in prairie voles.BMC genomics · 2022Article
- The Neurobiological Basis of Love: A Meta-Analysis of Human Functional Neuroimaging Studies of Maternal and Passionate Love.Brain sciences · 2022Review
- A structural connectivity atlas of limbic brainstem nuclei.Frontiers in neuroimaging · 2022Article
- Selectivity and Sociality: Aggression and Affiliation Shape Vole Social Relationships.Frontiers in behavioral neuroscience · 2022Review
- Population variation alters aggression-associated oxytocin and vasopressin expressions in brains of Brandt's voles in field conditions.Frontiers in zoology · 2021Article
- An Investgation About the Relationship Between Vasopressin and Oxytocin in Persistent Type Functional Neurological Symptom Disorder.Psychiatry investigation · 2021Article
- Pair Bond-Induced Affiliation and Aggression in Male Prairie Voles Elicit Distinct Functional Connectivity in the Social Decision-Making Network.Frontiers in neuroscience · 2021Article
- Coprophagy prevention alters microbiome, metabolism, neurochemistry, and cognitive behavior in a small mammal.The ISME journal · 2020Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- Paternal deprivation impairs social behavior putatively via epigenetic modification to lateral septum vasopressin receptor.Science advances · 2020Article
- The ventromedial hypothalamic circuitry and male alloparental behaviour in a socially monogamous rodent species.The European journal of neuroscience · 2019Article
- Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles.Scientific reports · 2019Article
- Affiliation, Aggression, and Selectivity of Peer Relationships in Meadow and Prairie Voles.Frontiers in behavioral neuroscience · 2019Article
- μ opioid receptor, social behaviour and autism spectrum disorder: reward matters.British journal of pharmacology · 2018Review
- Vasopressinergic Neurocircuitry Regulating Social Attachment in a Monogamous Species.Frontiers in endocrinology · 2017Review
- The Oxytocin-Vasopressin Pathway in the Context of Love and Fear.Frontiers in endocrinology · 2017Review
- The Brainstem in Emotion: A Review.Frontiers in neuroanatomy · 2017Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe neuropeptides vasopressin and corticotropin-releasing factor facilitate, while serotonin inhibits, aggression. How the brain is wired to coordinate interactions between these functionally opposed neurotransmitters to control behavioral states is poorly understood.
methodsPair-bonded male prairie voles (Microtus ochrogaster) were infused with a retrograde tracer, Fluoro-Gold, and tested for affiliation and aggression toward a female partner or novel female subject. Subsequent immunocytochemical experiments examined neuronal activation using Fos and neurochemical/neuroreceptor profiles on brain areas involved in these social behaviors. Finally, a series of behavioral pharmacologic and real-time in vivo brain microdialysis experiments were performed on male prairie voles displaying affiliation or aggression.
resultsWe localized a subpopulation of excitatory vasopressin neurons in the anterior hypothalamus that may gate corticotropin-releasing factor output from the amygdala to the anterior hypothalamus and then the lateral septum to modulate aggression associated with mate guarding. Conversely, we identified a subset of inhibitory serotonergic projection neurons in the dorsal raphe that project to the anterior hypothalamus and may mediate the spatiotemporal release of neuropeptides and their interactions in modulating aggression and affiliation.
conclusionsTogether, this study establishes the medial extended amygdala as a major neural substrate regulating the switch between positive and negative affective states, wherein several neurochemicals converge and interact to coordinate divergent social behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.