ArticleAnnals of biomedical engineering2016
Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus.
Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT.Heliyon · 2024Article
- Revealing the complexity of meniscus microvasculature through 3D visualization and analysis.Scientific reports · 2024Article
- A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties.Diagnostics (Basel, Switzerland) · 2022Article
- High Resolution Micro-Computed Tomography Reveals a Network of Collagen Channels in the Body Region of the Knee Meniscus.Annals of biomedical engineering · 2021Article
- Effects of human articular cartilage constituents on simultaneous diffusion of cationic and nonionic contrast agents.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- A Comparison of Dynamic and Static Hip-Knee-Ankle Angle during Gait in Knee Osteoarthritis Patients and Healthy Individuals.Applied bionics and biomechanics · 2021Article
- Diffusion of neutral solutes within human osteoarthritic cartilage: Effect of loading patterns.Journal of orthopaedic translation · 2020Article
- Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation.Annals of biomedical engineering · 2020Article
- Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging.Scientific reports · 2019Article
- Imaging of proteoglycan and water contents in human articular cartilage with full-body CT using dual contrast technique.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Molecular transport in articular cartilage - what have we learned from the past 50 years?Nature reviews. Rheumatology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Contrast enhanced computed tomography (CECT) is a non-destructive imaging technique used for the assessment of composition and structure of articular cartilage and meniscus. Due to structural and compositional differences between these tissues, diffusion and distribution of contrast agents may differ in cartilage and meniscus. The aim of this study is to determine the diffusion kinematics of a novel iodine based cationic contrast agent (CA(2+)) in cartilage and meniscus. Cylindrical cartilage and meniscus samples (d = 6 mm, h ≈ 2 mm) were harvested from healthy bovine knee joints (n = 10), immersed in isotonic cationic contrast agent (20 mgI/mL), and imaged using a micro-CT scanner at 26 time points up to 48 h. Subsequently, normalized X-ray attenuation and contrast agent diffusion flux, as well as water, collagen and proteoglycan (PG) contents in the tissues were determined. The contrast agent distributions within cartilage and meniscus were different. In addition, the normalized attenuation and diffusion flux were higher (p < 0.05) in cartilage. Based on these results, diffusion kinematics vary between cartilage and meniscus. These tissue specific variations can affect the interpretation of CECT images and should be considered when cartilage and meniscus are assessed simultaneously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.