Evidence map›Paper›PMID 27129358›Full record

Trial reportPsychosomatics

Effects of Positive Psychology Interventions on Risk Biomarkers in Coronary Patients: A Randomized, Wait-List Controlled Pilot Trial.

Gholam Reza Nikrahan, Johannes A C Laferton, Karim Asgari, Mehrdad Kalantari, Mohammad Reza Abedi, Ali Etesampour, Abbas Rezaei, Laura Suarez, Jeff C Huffman

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Frontiers in psychology · 2024
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  15. The role of behavioral science in addressing cardiovascular health disparities: A narrative review of efforts, challenges, and future directions.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gholam Reza NikrahanDepartment of Psychology, University of Isfahan, Isfahan, Iran; Department of Psychology, Islamic Azad University of Borujen, Borujen, Iran. Electronic address: rezanikrahan@yahoo.com.
Johannes A C LafertonDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
Karim AsgariDepartment of Psychology, University of Isfahan, Isfahan, Iran.
Mehrdad KalantariDepartment of Psychology, University of Isfahan, Isfahan, Iran.
Mohammad Reza AbediDepartment of Consulting, University of Isfahan, Isfahan, Iran.
Ali EtesampourDepartment of Internal Medicine, Najafabad Islamic Azad University, Najafabad, Iran.
Abbas RezaeiDepartment of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
Laura SuarezDepartment of Psychiatry, Harvard Medical School, Boston, MA; Department of Psychiatry, Massachusetts General HospitalBoston, MA.
Jeff C HuffmanDepartment of Psychiatry, Harvard Medical School, Boston, MA; Department of Psychiatry, Massachusetts General HospitalBoston, MA.

Funding

Developing a positive psychology intervention to improve cardiac health behaviorsR01HL113272 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HUFFMAN, JEFF C · 2013 to 2017
$2.6M
NHLBI NIH HHS R01 HL113272
6 · The paper itself

Abstract

backgroundAmong cardiac patients, positive psychologic factors are consistently linked with superior clinical outcomes and improvement in key markers of inflammation and hypothalamic-pituitary-adrenal axis functioning. Further, positive psychology interventions (PPI) have effectively increased psychologic well-being in a wide variety of populations. However, there has been minimal study of PPIs in cardiac patients, and no prior study has evaluated their effect on key prognostic biomarkers of cardiac outcome. Accordingly, we investigated the effect of 3 distinct PPIs on risk biomarkers in cardiac patients.

methodsIn an exploratory trial, 69 patients with recent coronary artery bypass graft surgery or percutaneous intervention were randomized to (1) one of three 6-week in-person PPIs (based on the work of Seligman, Lyubomirsky, or Fordyce) or (2) a wait-list control group. Risk biomarkers were assessed at baseline, postintervention (7 weeks), and at 15-week follow-up. Between-group differences in change from baseline biomarker levels were examined via random effects models.

resultsCompared with the control group, participants randomized to the Seligman (B = -2.06; p = 0.02) and Fordyce PPI (B = -1.54; p = 0.04) had significantly lower high-sensitivity C-reactive protein levels at 7 weeks. Further, the Lyubomirsky PPI (B = -245.86; p = 0.04) was associated with a significantly lower cortisol awakening response at 7 weeks when compared with control participants. There were no other significant between-group differences.

conclusionDespite being an exploratory pilot study with multiple between-group comparisons, this initial trial offers the first suggestion that PPIs might be effective in reducing risk biomarkers in high-risk cardiac patients.

Indexed as

AgedBiomarkersCoronary Artery BypassCoronary Artery DiseaseC-Reactive ProteinDepressionFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemInterleukin-1Interleukin-6MaleMiddle AgedPercutaneous Coronary InterventionPilot ProjectsBiomarkersC-Reactive ProteinHydrocortisoneIL6 protein, humanInterleukin-1Interleukin-6coronary artery diseaseHPA-axis functioninginflammationinterventionpositive psychologyrandomized controlled trial

Identifiers

PMID27129358
PMCPMC4902729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.