ArticlePLoS neglected tropical diseases2016
A Deep Insight into the Sialome of Rhodnius neglectus, a Vector of Chagas Disease.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Molecular Characterization ofInsects · 2025Article
- Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease.PLoS pathogens · 2024Review
- The biotechnological potential of proteases from hematophagous arthropod vectors.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Proteolytic activity ofThe journal of venomous animals and toxins including tropical diseases · 2021Article
- An Integrative Sialomic Analysis Reveals Molecules FromFrontiers in cellular and infection microbiology · 2021Article
- Salivary and Intestinal Transcriptomes Reveal Differential Gene Expression in Starving, Fed andFrontiers in cellular and infection microbiology · 2021Article
- Salivary proteins electrophoretic patterns enabled differentiating Colombian Rhodnius Trans-Andean and Cis-Andean groupsBiomedica : revista del Instituto Nacional de Salud · 2020Article
- Proteomic Mapping of Multifunctional Complexes Within Triatomine Saliva.Frontiers in cellular and infection microbiology · 2020Article
- Exploring the molecular complexity of Triatoma dimidiata sialome.Journal of proteomics · 2018Article
- An insight into the salivary gland and fat body transcriptome of Panstrongylus lignarius (Hemiptera: Heteroptera), the main vector of Chagas disease in Peru.PLoS neglected tropical diseases · 2018Article
- Salivary gland transcripts of the kissing bug, Panstrongylus chinai, a vector of Chagas disease.Acta tropica · 2017Article
- Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom's Biological Role.Toxins · 2017Article
- Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - a review.Parasites & vectors · 2017Review
- Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundTriatomines are hematophagous insects that act as vectors of Chagas disease. Rhodnius neglectus is one of these kissing bugs found, contributing to the transmission of this American trypanosomiasis. The saliva of hematophagous arthropods contains bioactive molecules responsible for counteracting host haemostatic, inflammatory, and immune responses. METHODS/PRINCIPAL
findingsNext generation sequencing and mass spectrometry-based protein identification were performed to investigate the content of triatomine R. neglectus saliva. We deposited 4,230 coding DNA sequences (CDS) in GenBank. A set of 636 CDS of proteins of putative secretory nature was extracted from the assembled reads, 73 of them confirmed by proteomic analysis. The sialome of R. neglectus was characterized and serine protease transcripts detected. The presence of ubiquitous protein families was revealed, including lipocalins, serine protease inhibitors, and antigen-5. Metalloproteases, disintegrins, and odorant binding protein families were less abundant. CONCLUSIONS/SIGNIFICANCE: The data presented improve our understanding of hematophagous arthropod sialomes, and aid in understanding hematophagy and the complex interplay among vectors and their vertebrate hosts.
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Registered trials
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