Evidence map›Paper›PMID 27129102›Full record

ReviewPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2016

How relevant is panallergen sensitization in the development of allergies?

Olivia E McKenna, Claudia Asam, Galber R Araujo, Anargyros Roulias, Luiz R Goulart, Fatima Ferreira

Open access · hybridAbstract readReview
In one paragraph

Review in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Article
  3. Calcium-binding proteins as allergens.Frontiers in allergy · 2026
    Review
  4. Association of allergen stability and epithelial barrier function in sensitized patients.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Sensitization pattern to environmental allergens in a Japanese population.The journal of allergy and clinical immunology. Global · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Olivia E McKennaDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
Claudia AsamDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
Galber R AraujoDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
Anargyros RouliasDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
Luiz R GoulartLaboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of Uberlandia, Uberlandia, Brazil.
Fatima FerreiraDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
University of Salzburg · ATUniversity of California, Davis · US

Funding

Austrian Science Fund FWF P 27589Austrian Science Fund FWF W 1213
6 · The paper itself

Abstract

Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitized to panallergens are outlined, and the use of panallergens as predictors for cross-reactive allergy and as biomarkers for disease severity is discussed.

Indexed as

Cross ReactionsAllergensAnimalsAntigens, PlantBiomarkersFoodHumansHypersensitivityImmunoglobulin EPollenPredictive Value of TestsTropomyosinAllergensAntigens, PlantBiomarkersImmunoglobulin ETropomyosinallergy diagnosisallergy treatmentIgE cross-reactivitynon-specific lipid transfer proteinspathogenesis-related protein family 10polcalcinsprofilinstropomyosin

Identifiers

PMID27129102
PMCPMC5006871
OpenAlexW2345288088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.