ArticleAlzheimer disease and associated disorders
Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 43 citations in OpenAlex.
- Leveraging Naturalistic Driving Digital Biomarkers for Early Mild Cognitive Impairment Detection: Deep Learning Strategies.JMIR medical informatics · 2026Article
- Lost before forgetting: objective driving metrics track navigation deficits tied to preclinical Alzheimer's disease.Innovation in aging · 2026Article
- Association of Daily Driving Behaviors With Mild Cognitive Impairment in Older Adults Followed Over 10 Years.Neurology · 2025Observational
- A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia.Scientific data · 2025Article
- Falls and Alzheimer Disease.Advances in geriatric medicine and research · 2024Article
- Adverse driving behaviors increase over time as a function of preclinical Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Article
- Associations Between Plasma, Imaging, and Cerebrospinal Fluid Biomarkers with Driving Behavior and Cognitive Tests: Implications for Biomarker Usefulness.Journal of Alzheimer's disease reports · 2023Article
- Everyday Driving and Plasma Biomarkers in Alzheimer's Disease: Leveraging Artificial Intelligence to Expand Our Diagnostic Toolkit.Journal of Alzheimer's disease : JAD · 2023Article
- Driving assessment in preclinical Alzheimer's disease: progress to date and the path forward.Alzheimer's research & therapy · 2022Review
- Article
- Improving Our Understanding of Driving Changes in Preclinical and Early Symptomatic Alzheimer's Disease: The Role of Naturalistic Driving Studies.Journal of Alzheimer's disease reports · 2022Review
- Cognitive and brain reserve predict decline in adverse driving behaviors among cognitively normal older adults.Frontiers in psychology · 2022Article
- Predicting driving decline and assessing crash risk in a globally aging population.Arquivos de neuro-psiquiatria · 2022Article
- Using Naturalistic Driving Data to Predict Mild Cognitive Impairment and Dementia: Preliminary Findings from the Longitudinal Research on Aging Drivers (LongROAD) Study.Geriatrics (Basel, Switzerland) · 2021Article
- Identifying Preclinical Alzheimer's Disease Using Everyday Driving Behavior: Proof of Concept.Journal of Alzheimer's disease : JAD · 2021Article
- Recruitment of African American and Non-Hispanic White Older Adults for Alzheimer Disease Research Via Traditional and Social Media: a Case Study.Journal of cross-cultural gerontology · 2020Article
- The Role of Eye Tracking Technology in Assessing Older Driver Safety.Geriatrics (Basel, Switzerland) · 2020Review
- Differences in Driving Outcomes Among Cognitively Normal African American and Caucasian Older Adults.Journal of racial and ethnic health disparities · 2020Article
- Driving Safety of Cognitively-Impaired Drivers Based on Near Collisions in Naturalistic Driving.Journal of Alzheimer's disease reports · 2020Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 2 countries.
Funding
Abstract
Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/Aβ42). Higher ratios of CSF tau/Aβ42, ptau181/Aβ42, and PIB mean cortical binding potential, were associated with more driving errors (P<0.05). Preclinical AD may have subtle cognitive and functional effects, which alone may go unnoticed. However, when combined, these changes may impact complex behaviors such as driving.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.