SynthesisInternational journal of occupational and environmental health2016
Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review.
Synthesis in International journal of occupational and environmental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Pesticide safe use practice and acute health symptoms, and associated factors among farmers in developing countries: a systematic review and meta-analysis of an epidemiological evidence.BMC public health · 2024Pooled it
- Risk Factors for Brain Health in Agricultural Work: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review.Frontiers in human neuroscience · 2021Pooled it
- Farming exposures and Alzheimer's disease: cross-sectional analysis within the French AGRICAN cohort.Scandinavian journal of work, environment & health · 2026Article
- Risk-based mapping of pesticide usage and social vulnerability in the contiguous United States.BMC public health · 2025Article
- Endophytic and Epiphytic Microorganisms as Biocontrol Agents: Mechanisms, Applications, and Metagenomic Approaches in Tomato Cultivation.Molecules (Basel, Switzerland) · 2025Review
- An Exposome-Wide Interaction Study to Identify Hidden Environmental Factors Affecting Susceptible Populations: Application to Chemical-Social Vulnerability Interactions on Cognitive Function.medRxiv : the preprint server for health sciences · 2025Article
- Comprehensive Biomarker Assessment of Pesticide Exposure and Telomere Attrition in Mexican Children from Agricultural Communities.Journal of xenobiotics · 2025Article
- Integrated Management Strategies for Blackleg Disease of Canola Amidst Climate Change Challenges.Journal of fungi (Basel, Switzerland) · 2025Review
- Neurological and organ health risks associated with pesticide mixture exposure in banana farm workers in Moungo Division, Cameroon.Scientific reports · 2025Article
- An Integrated Nanosensor/Smartphone Platform for Point-of-Care Biomonitoring of Human Exposure to Pesticides.Analytical chemistry · 2025Article
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Assessment of the toxic influence of locally formulated pesticides on hepatic and renal biomarkers in male Wistar rats.Toxicology research · 2024Article
- Pesticide Exposure in the Cultivation ofInternational journal of environmental research and public health · 2024Article
- Housing Conditions and Health Implications for Migrant Agricultural Workers in Canada: A Scoping Review.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2024Article
- Association of pesticide exposure with neurobehavioral outcomes among avocado farmworkers in Mexico.International journal of hygiene and environmental health · 2024Article
- Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction.International journal of molecular sciences · 2024Review
- Investigating the prevalence of erectile dysfunction among men exposed to organophosphate insecticides.Journal of endocrinological investigation · 2024Article
- Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders.Neuropsychiatric disease and treatment · 2024Review
- Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study.Toxicology reports · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated that acute poisoning from exposure to organophosphate (OP) pesticides in agricultural workers causes adverse health effects. However, neuropsychological and cognitive effects of chronic occupational exposure to OP pesticides remain controversial.
objectiveTo identify, evaluate, and systematize existing evidence regarding chronic exposure to OP pesticides and neuropsychological effects in farmworkers.
methodsUsing the PubMed search engine, a systematic review process was implemented and replicated according to the PRISMA statement. Eligibility criteria included workers over 18 years of age exposed to OP pesticides as well as assessment of neuropsychological and cognitive functioning. Search terms were in English and Spanish languages and included organophosphate and workers.
resultsOf the search results, 33 of 1,256 articles meet eligibility criteria. Twenty-four studies found an association between chronic occupational exposure to OP pesticides and low neuropsychological performance in workers. We classified nine of the studies to have study design limitations. Studies indicated occupational exposure to OP pesticides is linked to difficulties in executive functions, psychomotor speed, verbal, memory, attention, processing speed, visual-spatial functioning, and coordination. Nine studies find no relationship between OP pesticides exposure and neuropsychological performance.
conclusionsOverall, evidence suggests an association between chronic occupational exposure to OP pesticides and neuropsychological effects. However, there is no consensus about the specific cognitive skills affected.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.