ReviewRNA biology2016
7SKiing on chromatin: Move globally, act locally.
Review in RNA biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes.Molecular cell · 2025Article
- A (Scientific) Lifetime Affair With Nucleic Acids.Journal of molecular biology · 2025Review
- KAP1 in antiviral immunity: dual roles in viral silencing and immune regulation.Frontiers in cellular and infection microbiology · 2025Review
- The HIV-1 Transcriptional Program: From Initiation to Elongation Control.Journal of molecular biology · 2025Review
- 3D chromatin structures associated with ncRNAScience advances · 2024Article
- KAP1 modulates osteogenic differentiation via the ERK/Runx2 cascade in vascular smooth muscle cells.Molecular biology reports · 2023Article
- An alternative D. melanogaster 7SK snRNP.BMC molecular and cell biology · 2021Article
- CDK9 keeps RNA polymerase II on track.Cellular and molecular life sciences : CMLS · 2021Review
- Review
- The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.Cytokine & growth factor reviews · 2021Review
- HIV-1 Proviral Transcription and Latency in the New Era.Viruses · 2020Review
- KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.Experimental cell research · 2019Article
- Transcriptional Circuit Fragility Influences HIV Proviral Fate.Cell reports · 2019Article
- CDK9: a signaling hub for transcriptional control.Transcription · 2019Review
- P-TEFb Regulates Transcriptional Activation in Non-coding RNA Genes.Frontiers in genetics · 2019Article
- Hexim1, an RNA-controlled protein hub.Transcription · 2018Review
- Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells.Journal of visualized experiments : JoVE · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies suggest that P-TEFb (as part of the inhibitory 7SK snRNP) is recruited to promoter-proximal regions through interaction with KAP1/TRIM28/TIF1β to facilitate 'on-site' kinase activation and transcription elongation. Here, I discuss features of this model and future challenges to further hone our understanding of transcriptional regulation including Pol II pausing and pause release.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.