Evidence map›Paper›PMID 27127763›Full record

ReviewAnnals of translational medicine2016

Predictive value of BRCA1 expression on the efficacy of chemotherapy based on anti-microtubule agents: a pooled analysis across different malignancies and agents.

Qihua He, Mingzhe Zhang, Jianrong Zhang, Shengyi Zhong, Yang Liu, Jianfei Shen, Jiaxi He, Long Jiang, Chenglin Yang, Yuan Zeng and 4 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Qihua He1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Mingzhe Zhang1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Jianrong Zhang1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Shengyi Zhong1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Yang Liu1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Jianfei Shen1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Jiaxi He1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Long Jiang1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Chenglin Yang1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Yuan Zeng1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Minzhang Guo1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Xuewei Chen1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Jianxing He1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
Wenhua Liang1 Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease, Guangzhou 510000, China ; 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen 361000, China.
First Affiliated Hospital of Guangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer susceptibility gene 1 (BRCA1) expression has been suggested as a predictor in anti-neoplastic treatment with anti-microtubule agents. However, the existing evidence is conflicting. Consulting the literature, we sought to examine the true impact of BRCA1 expression on the efficacy of anti-microtubule agents.

methodsMedline by PubMed and Embase databases were searched for eligible studies. The primary endpoints were objective response rate (ORR) and progression free survival (PFS). Additional subgroup analyses stratified for detection methods, regimen, and patient origin were also performed.

resultsA total of 13 relevant studies involving a total of 1,490 cases were enrolled. Involved agents included paclitaxel, docetaxel and vinorelbine; Malignancies included non-small cell lung cancer, gastric cancer, esophageal carcinoma, ovarian carcinoma, malignant pleural mesothelioma, breast cancer, and small cell lung cancer. Through meta-analyses, we observed a potentially greater ORR in the population with high BRCA1 expression vs. low BRCA1 expression (OR 1.63, 95% CI: 0.92 to 2.88, P=0.09) but the heterogeneity is severe (P=0.01; I(2)=61%). Similar results were observed in PFS (high vs. low expression, HR 0.93, 95% CI: 0.75 to 1.15, P=0.49; heterogeneity, P<0.01, I(2)=75%). After stratification by testing methods, a significantly higher ORR in the population with high BRCA1 expression was shown in the subgroup using mRNA as a quantitative method (OR 2.90, 95% CI: 1.92 to 4.39, P<0.01; I(2)=0) whereas the difference in the subgroup using immunohistochemistry (IHC) was not significant (OR 0.60, 95% CI: 0.33 to 1.10, P=0.10; I(2)=0). Stratification by regimen (platinum-based vs. non platinum-based) and patient origin (Asian vs. Caucasian) did not reduce the heterogeneity.

conclusionsAlthough the predictive value of BRCA1 expression on the anti-microtubule chemotherapy remained uncertain based on overall results, our exploratory analyses suggested that detection using mRNA might be a preferred technique, however, further validation is required to substantiate our findings.

Indexed as

anti-microtubule agentsBreast cancer susceptibility gene 1 (BRCA1)meta-analysis

Identifiers

PMID27127763
PMCPMC4828752
OpenAlexW2321419128

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.