ArticleInternational journal of applied & basic medical research
Aqueous leaf extract of Ocimum gratissimum improves hematological parameters in alloxan-induced diabetic rats via its antioxidant properties.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 33 citations in OpenAlex.
- Phytochemical screening, UPLC analysis, evaluation of synergistic antioxidant and antibacterial efficacy of three medicinal plants used in Kinshasa, D.R. Congo.Scientific reports · 2025Article
- An ethnopharmacological assessment of medicinal plants in Malanje Municipality, Angola.Frontiers in pharmacology · 2025Article
- Article
- Network pharmacology based anti-diabetic attributes of bioactive compounds fromSaudi journal of biological sciences · 2023Article
- Article
- Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats.BMC complementary medicine and therapies · 2021Article
- A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Heliyon · 2021Review
- Antioxidative properties ofToxicology reports · 2021Article
- Nephroprotective effect ofJournal of traditional and complementary medicine · 2021Article
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Abstract
objectiveThis study was designed to investigate the effects of Ocimum gratissimum (OG) on hematological parameters and oxidative stress in diabetic rats. MATERIALS AND
methodsTwenty-five male rats (150-200 g) were randomly grouped into five as control, normal + OG, diabetic untreated, diabetic + OG, and diabetic + glibenclamide groups. Diabetes was induced by 100 mg/kg of alloxan monohydrate in the diabetic untreated and diabetic + OG groups followed by treatment with distilled water and 400 mg/kg OG, respectively, whereas control, normal + OG, and diabetic + glibenclamide groups were treated with distilled water, 400 mg/kg OG, and 5 mg/kg glibenclamide, respectively. Body weight and fasting blood glucose level were monitored weekly. After 28 days of treatments, under anesthesia induced by 50 mg/kg sodium thiopental i.p., blood samples were obtained for hematological analysis, malondialdehyde (MDA) level determination, and superoxide dismutase (SOD) activity. Data were compared using analysis of variance and Student's t-test.
resultsThere was a significant decrease in the fasting blood glucose of the diabetic + OG animals compared to the diabetic untreated and the initial reduction in weight observed in this group was reversed at the end of the experiments. Packed cell volume, red blood cell count, and hemoglobin concentration were significantly increased (P < 0.05) in the diabetic + OG when compared with the untreated group. The MDA concentration was significantly lowered (P < 0.01) in the diabetic + OG group when compared with diabetic untreated while SOD activity was significantly reduced in the diabetic untreated group.
conclusionIt was concluded that OG reverses anemia secondary to alloxan-induced diabetes mellitus in rats probably via its antioxidant activity.
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