ArticleBrain and behavior2016
Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- The clinical profile of cerebral small vessel disease: Toward an evidence-based identification of cognitive markers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults.Scientific reports · 2023Article
- Association between cognitive capacity and metabolic indices in patients with neuropsychiatric disorders.Journal of education and health promotion · 2023Article
- Free Triiodothyronine Levels are Related to Executive Function and Scene Memory in Type 2 Diabetes Mellitus Patients Without Diagnosed Thyroid Diseases.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Thyroid Hormones Level and Cognition in the Recovery Stage of Stroke Patients with Cognitive Dysfunction.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The clinical use of blood-test factors for Alzheimer's disease: improving the prediction of cerebral amyloid deposition by the QPLEXExperimental & molecular medicine · 2021Article
- Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease.Frontiers in neurology · 2020Article
- Emerging Biomarkers in Vascular Cognitive Impairment and Dementia: From Pathophysiological Pathways to Clinical Application.International journal of molecular sciences · 2019Review
- Metabolic Plasticity of Astrocytes and Aging of the Brain.International journal of molecular sciences · 2019Review
- Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease.Brain and behavior · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, the relationship between thyroid dysfunction and subcortical ischemic vascular disease (SIVD)-induced cognitive impairments still remains elusive.
methodsCognitive performances were examined in 215 participants, including 54 healthy participants, 52 SIVD patients with no dementia (SIVDND), 55 patients with mild cognitive impairment (SVMCI), and 54 patients with vascular dementia (VD). Serum thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4) and free thyroxine (FT4), thyroglobulin antibody (TGA), and antithyroid peroxidase antibody (TPO-Abs) were quantified by radioimmunoassay or ELISA.
resultsA close correlation between thyroid status and cognitive dysfunction in SIVD was observed. Serum TT3 and FT3 levels decreased, whereas serum TSH level increased, with the decline in cognitive functions. Furthermore, TT3 levels showed a positive correlation, whereas TSH level showed a negative correlation, with the Mini-Mental State Examination (MMSE) scores. Our results suggested that thyroid function was associated with cognitive impairments induced by SIVD. Also, thyroid function and thyroid hormone level could be a risk factor in the development of SIVD. Serum TT3 and TSH levels might also be used as biomarkers for cognitive dysfunction.
conclusionsThese findings might contribute to a more accurate clinical diagnosis and differentiation among normal controls, SIVDND, SVMCI, and VD patients, in order to develop appropriate intervention approaches for SIVD therapeutic treatment.
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