Evidence map›Paper›PMID 27127722›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2016

Post-mortem Findings in Huntington's Deep Brain Stimulation: A Moving Target Due to Atrophy.

Vinata Vedam-Mai, Daniel Martinez-Ramirez, Justin D Hilliard, Samuel Carbunaru, Anthony T Yachnis, Joshua Bloom, Peyton Keeling, Lisa Awe, Kelly D Foote, Michael S Okun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Deep brain stimulation in Huntington's disease: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  3. An Update on the Treatment of Chorea.Current treatment options in neurology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Vinata Vedam-MaiDepartment of Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Daniel Martinez-RamirezDepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Justin D HilliardDepartment of Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Samuel CarbunaruDepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Anthony T YachnisDepartment of Pathology, University of Florida, Gainesville, FL, USA.
Joshua BloomDepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Peyton KeelingDepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Lisa AweDepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Kelly D FooteDepartment of Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Michael S OkunDepartment of Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA; Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
University of Florida · US

Funding

Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) has been shown to be effective for Parkinson's disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington's disease (HD). CASE REPORT: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. DISCUSSION: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.

Indexed as

atrophychoreaDeep brain stimulationelectrode designhistopathologyHuntington’s disease

Identifiers

PMID27127722
PMCPMC4848757
OpenAlexW2343407993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.