ReviewBoneKEy reports2012
Genetic aspects of skeletal muscle strength and mass with relevance to sarcopenia.
Review in BoneKEy reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Sex-specific physical activity thresholds influencing muscle function in older adults with XX genotype of ACTN3 R577X.Scientific reports · 2026Article
- Does a Validated Circum-menarcheal Arm Bone-Loading Index Predict Post-menarcheal Muscle Function in Adolescent Females?Journal of musculoskeletal & neuronal interactions · 2026Article
- Multi-Omics Profiling of Individuals Sustaining Extreme Physical Stressors.Life (Basel, Switzerland) · 2025Review
- Exploration of Pathogenesis and Cutting-Edge Treatment Strategies of Sarcopenia: A Narrative Review.Clinical interventions in aging · 2025Review
- The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults.Biomedicines · 2024Article
- Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Acute responses of strength-related gene expressions to maximum strength and force sense acuity.Turkish journal of medical sciences · 2024Article
- Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice.NPJ microgravity · 2023Article
- Lean nonalcoholic fatty liver disease and sarcopenia.Frontiers in endocrinology · 2023Review
- The Association between theGenes · 2022Article
- Sit to stand muscle power reference values and their association with adverse events in Colombian older adults.Scientific reports · 2022Article
- Genetic factors contributing to late adverse musculoskeletal effects in childhood acute lymphoblastic leukemia survivors.The pharmacogenomics journal · 2022Article
- Maternal excess adiposity and serum 25-hydroxyvitamin D < 50 nmol/L are associated with elevated whole body fat mass in healthy breastfed neonates.BMC pregnancy and childbirth · 2022Article
- Genes and Weightlifting Performance.Genes · 2021Article
- Influence of Polymorphism on theJournal of personalized medicine · 2021Article
- Diet and Exercise Are not Associated with Skeletal Muscle Mass and Sarcopenia in Patients with Bladder Cancer.European urology oncology · 2021Article
- Responses to Maximal Strength Training in Different Age and Gender Groups.Frontiers in physiology · 2021Article
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- Sarcopenia in aging, obesity, and cancer.Translational cancer research · 2020Article
- Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single-nucleotide polymorphisms in elite master athletes.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle is a highly heritable quantitative trait, with heritability estimates ranging 30-85% for muscle strength and 50-80% for lean mass. That strong genetic contribution indicates the possibility of using genetic information to individualize treatments for sarcopenia or even aid in prevention strategies through the use of genetic screening prior to the functional limitations. Though these possibilities provide the rationale for genetic studies of skeletal muscle traits, few genes have been identified that appear to contribute to variation in either skeletal muscle strength or mass phenotypes, and sarcopenia per se is remarkably understudied as a trait in this regard. This review examines the heritability of skeletal muscle traits, findings of linkage and genome-wide association analyses and impact of specific genes and gene-sequence variants on these traits as relevant to sarcopenia. Despite considerable work in the area, the genetic underpinnings of skeletal muscle traits remain largely unknown and the genetic aspects of sarcopenia are even less clear. Large-scale longitudinal clinical studies relying on advanced genome-wide association and other techniques are needed to provide further insights into the genes and gene variants that contribute to skeletal muscle strength and mass, and ultimately to susceptibility to sarcopenia.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.