ArticleNeural regeneration research2016
Substance P combined with epidermal stem cells promotes wound healing and nerve regeneration in diabetes mellitus.
Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Biomaterial-assisted neuralization strategies for tissue engineering applications.Materials today. Bio · 2026Review
- Article
- A comparative study of the established methods and evaluation of rat trauma models.Animal models and experimental medicine · 2025Article
- Role of neurotransmitters in the regulation of cutaneous wound healing.Experimental brain research · 2022Review
- The Regenerative Potential of Substance P.International journal of molecular sciences · 2022Review
- Research status and hot topics of the effects of skin innervation on wound healing from 1959 to 2022: A bibliometric analysis.Frontiers in surgery · 2022Article
- New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers.Foods (Basel, Switzerland) · 2021Review
- Wound healing: cellular mechanisms and pathological outcomes.Open biology · 2020Review
- Substance P enhances the local activation of NKBMC molecular and cell biology · 2020Article
- Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides.Autonomic neuroscience : basic & clinical · 2020Review
- Pharmacological Properties of the Medical Maggot: A Novel Therapy Overview.Evidence-based complementary and alternative medicine : eCAM · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exogenous substance P accelerates wound healing in diabetes, but the mechanism remains poorly understood. Here, we established a rat model by intraperitoneally injecting streptozotocin. Four wounds (1.8 cm diameter) were drilled using a self-made punch onto the back, bilateral to the vertebral column, and then treated using amniotic membrane with epidermal stem cells and/or substance P around and in the middle of the wounds. With the combined treatment the wound-healing rate was 100% at 14 days. With prolonged time, type I collagen content gradually increased, yet type III collagen content gradually diminished. Abundant protein gene product 9.5- and substance P-immunoreactive nerve fibers regenerated. Partial nerve fiber endings extended to the epidermis. The therapeutic effects of combined substance P and epidermal stem cells were better than with amniotic membrane and either factor alone. Our results suggest that the combination of substance P and epidermal stem cells effectively contributes to nerve regeneration and wound healing in diabetic rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.