Evidence map›Paper›PMID 27127388›Full record

ArticleJournal of pharmacology & pharmacotherapeutics

Asenapine modulates nitric oxide release and calcium movements in cardiomyoblasts.

Elena Grossini, Carla Gramaglia, Serena Farruggio, Lara Camillo, David Mary, Giovanni Vacca, Patrizia Zeppegno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacology & pharmacotherapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena GrossiniDepartment of Translational Medicine, Laboratory of Physiology and Experimental Surgery, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy; Azienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy.
Carla GramagliaAzienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy; Department of Translational Medicine, Psichiatric Unit, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy.
Serena FarruggioDepartment of Translational Medicine, Laboratory of Physiology and Experimental Surgery, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy; Azienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy.
Lara CamilloAzienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy; Department of Translational Medicine, Psichiatric Unit, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy.
David MaryDepartment of Translational Medicine, Laboratory of Physiology and Experimental Surgery, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy; Azienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy.
Giovanni VaccaDepartment of Translational Medicine, Laboratory of Physiology and Experimental Surgery, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy; Azienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy.
Patrizia ZeppegnoAzienda Ospedaliera Universitaria Maggiore Della Carità, Corso Mazzini 36, Novara, Italy; Department of Translational Medicine, Psichiatric Unit, University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, I-28100, Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the effects of asenapine on nitric oxide (NO) release and Ca(2+) transients in H9C2 cell line, which were either subjected to peroxidation or not. MATERIALS AND

methodsH9C2 were treated with asenapine alone or in presence of intracellular kinase blockers, serotoninergic and dopaminergic antagonists, and voltage Ca(2+) channels inhibitors. Experiments were also performed in H9C2 treated with hydrogen peroxide. NO release and intracellular Ca(2+) were measured through specific probes.

resultsIn H9C2, asenapine differently modulated NO release and Ca(2+) movements depending on peroxidative condition. The Ca(2+) pool mobilized by asenapine mainly originated from the extracellular space and was slightly affected by thapsigargin. Moreover, the effects of asenapine were reduced or prevented by kinases blockers, dopaminergic and serotoninergic receptors inhibitors, and voltage Ca(2+) channels blockers.

conclusionsOn the basis of our findings, we can conclude that asenapine by interacting with its specific receptors, exerts dual effects on NO release and Ca(2+) homeostasis in H9C2; this would be of particular clinical relevance when considering their role in cardiac function modulation.

Indexed as

Antipsychoticscalcium transientsdopaminergic receptorsserotoninergic receptorsvoltage channels

Identifiers

PMID27127388
PMCPMC4831496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.