ArticleProceedings of SPIE--the International Society for Optical Engineering2016
Structural Functional Associations of the Orbit in Thyroid Eye Disease: Kalman Filters to Track Extraocular Rectal Muscles.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Computed tomography and magnetic resonance imaging approaches to Graves' ophthalmopathy: a narrative review.Frontiers in endocrinology · 2023Review
- Global research of artificial intelligence in strabismus: a bibliometric analysis.Frontiers in medicine · 2023Article
- Assessment of Orbital Computed Tomography (CT) Imaging Biomarkers in Patients with Thyroid Eye Disease.Journal of digital imaging · 2019Article
- Electronic Medical Record Context Signatures Improve Diagnostic Classification Using Medical Image Computing.IEEE journal of biomedical and health informatics · 2019Article
- Imaging biomarkers in thyroid eye disease and their clinical associations.Journal of medical imaging (Bellingham, Wash.) · 2018Article
- QUADRATIC: Quality of Dice in Registration Circuits.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Structural-Functional Relationships Between Eye Orbital Imaging Biomarkers and Clinical Visual Assessments.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Phenotype Analysis of Early Risk Factors from Electronic Medical Records Improves Image-Derived Diagnostic Classifiers for Optic Nerve Pathology.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- EMR-Radiological Phenotypes in Diseases of the Optic Nerve and their Association with Visual Function.Deep learning in medical image analysis and multimodal learning for clinical decision support : Third International Workshop, DLMIA 2017, and 7th International Workshop, ML-CDS 2017, held in conjunction with MICCAI 2017 Quebec City, QC,... · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Pathologies of the optic nerve and orbit impact millions of Americans and quantitative assessment of the orbital structures on 3-D imaging would provide objective markers to enhance diagnostic accuracy, improve timely intervention and eventually preserve visual function. Recent studies have shown that the multi-atlas methodology is suitable for identifying orbital structures, but challenges arise in the identification of the individual extraocular rectus muscles that control eye movement. This is increasingly problematic in diseased eyes, where these muscles often appear to fuse at the back of the orbit (at the resolution of clinical computed tomography imaging) due to inflammation or crowding. We propose the use of Kalman filters to track the muscles in three-dimensions to refine multi-atlas segmentation and resolve ambiguity due to imaging resolution, noise, and artifacts. The purpose of our study is to investigate a method of automatically generating orbital metrics from CT imaging and demonstrate the utility of the approach by correlating structural metrics of the eye orbit with clinical data and visual function measures in subjects with thyroid eye disease. The pilot study demonstrates that automatically calculated orbital metrics are strongly correlated with several clinical characteristics. Moreover, the superior, inferior, medial and lateral rectus muscles obtained using Kalman filters are each correlated with different categories of functional deficit. These findings serve as foundation for further investigation in the use of CT imaging in the study, analysis and diagnosis of ocular diseases, specifically thyroid eye disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.