ReviewPhysiology & behavior2016
Circuit organization of sugar reinforcement.
Review in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- An enzymatic-metabolic sensing axis in taste cells detects glucose-yielding carbohydrates.bioRxiv : the preprint server for biology · 2026Article
- A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025Article
- AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.Communications biology · 2025Article
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- Associations of body roundness index and sugar-sweetened beverage consumption with psychological symptoms in adolescents: a multicenter cross-sectional survey based on Chinese adolescents aged 12-18 years old.Frontiers in nutrition · 2025Article
- Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating.Cell metabolism · 2024Article
- Dietary experience with glucose and fructose fosters heightened avidity for glucose-containing sugars independent of TRPM5 taste transduction in mice.Nutritional neuroscience · 2023Article
- Actions and Consequences of Insulin in the Striatum.Biomolecules · 2023Review
- Immune sensing of food allergens promotes aversive behaviour.bioRxiv : the preprint server for biology · 2023Article
- Confection Confusion: Interplay Between Diet, Taste, and Nutrition.Trends in endocrinology and metabolism: TEM · 2021Review
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- The Role of Post-Ingestive Feedback in the Development of an Enhanced Appetite for the Orosensory Properties of Glucose over Fructose in Rats.Nutrients · 2020Article
- From appetite setpoint to appetition: 50years of ingestive behavior research.Physiology & behavior · 2018Review
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila.Nature communications · 2017Article
- Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making.Scientific reports · 2017Article
- Physiologic and Neural Controls of Eating.Gastroenterology clinics of North America · 2016Review
- Homeostasis Meets Motivation in the Battle to Control Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Reassessing wanting and liking in the study of mesolimbic influence on food intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Activation of Dopamine Receptors in the Nucleus Accumbens Promotes Sucrose-Reinforced Cued Approach Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Sugar's potent reinforcing properties arise from the complex interplay between gustatory and nutritive signals. This commentary addresses a unique organizational aspect of the neuronal circuitry that mediates sugar reinforcement in both Drosophila and rodents. Specifically, current evidence supports a general circuit model where separate populations of dopaminergic neurons encode the gustatory and nutritive values of sugar. This arrangement allows animals to prioritize energy seeking over taste quality, and implies that specialized subpopulations of dopamine-containing neurons form a class of evolutionary conserved chemo- and nutrient-sensors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.