ArticleDiabetes & metabolism journal2016
Importance of Lean Muscle Maintenance to Improve Insulin Resistance by Body Weight Reduction in Female Patients with Obesity.
Article in Diabetes & metabolism journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Association between insulin sensitivity and lean mass loss during weight loss.Obesity (Silver Spring, Md.) · 2024Trial
- Dietary behaviour change intervention for managing sarcopenic obesity among community-dwelling older people: a pilot randomised controlled trial.BMC geriatrics · 2023Trial
- Effects of a multicomponent intervention on body composition and cardiovascular risk factors in women with obesity- a randomized clinical trial.Journal of diabetes and metabolic disorders · 2025Article
- Consequences of Dietary Manganese-Based Nanoparticles Supplementation or Deficiency on Systemic Health and Gut Metabolic Dynamics in Rats.Nanotechnology, science and applications · 2025Article
- Branched-Chain and Aromatic Amino Acids in Relation to Fat Mass and Fat-Free Mass Changes among Adolescents: A School-Based Intervention.Metabolites · 2022Article
- Exercise and Nutrition Strategies for Combating Sarcopenia and Type 2 Diabetes Mellitus in Older Adults.Journal of functional morphology and kinesiology · 2022Review
- Interrelationship of Gut Microbiota, Obesity, Body Composition and Insulin Resistance in Asians with Type 2 Diabetes Mellitus.Journal of personalized medicine · 2022Article
- Exercise induces favorable metabolic changes in white adipose tissue preventing high-fat diet obesity.Physiological reports · 2021Article
- The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program.BMC endocrine disorders · 2021Article
- Exercising for Insulin Sensitivity - Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?Frontiers in physiology · 2021Review
- Effects of low skeletal muscle mass and sarcopenic obesity on albuminuria: a 7-year longitudinal study.Scientific reports · 2020Article
- Changes in Body Composition andDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Physical Activity Earlier in Life Is Inversely Associated With Insulin Resistance Among Adults in Japan.Journal of epidemiology · 2019Article
- Reduced Lean Body Mass and Cardiometabolic Diseases in Adult Males with Overweight and Obesity: A Pilot Study.International journal of environmental research and public health · 2018Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Influence of segmental body composition and adiposity hormones on resting metabolic rate and substrate utilization in overweight and obese adults.Journal of endocrinological investigation · 2017Article
- Lipid modulation of skeletal muscle mass and function.Journal of cachexia, sarcopenia and muscle · 2017Review
- Carbohydrate-Restriction with High-Intensity Interval Training: An Optimal Combination for Treating Metabolic Diseases?Frontiers in nutrition · 2017Article
- Comparison of the behavioral effects of exercise and high fat diet on cognitive function in adolescent rats.Journal of exercise rehabilitation · 2016Article
- Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects.Diabetes & metabolism journal · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has recently been suggested that skeletal muscle has an important role in insulin resistance in obesity, in addition to exercise tolerance and the fat index. The aim of this study was to identify body composition factors that contribute to improvement of insulin resistance in female patients with obesity who reduce body weight.
methodsWe studied 92 female obese patients (age 40.9±10.4 years, body mass index 33.2±4.6 kg/m²) who reduced body weight by ≥5% after an intervention program including diet, exercise therapy, and cognitive behavioral therapy. Before and after the intervention, body composition was evaluated by dual-energy X-ray absorptiometry to examine changes in skeletal muscle mass. Homeostasis model assessment of insulin resistance (HOMA-IR) was measured as an index of insulin resistance. Cardiopulmonary exercise was also performed by all patients.
resultsThere were significant improvements in body weight (-10.3%±4.5%), exercise tolerance (anaerobic threshold oxygen uptake 9.1%±18.4%, peak oxygen uptake 11.0%±14.2%), and HOMA-IR (-20.2%±38.3%). Regarding body composition, there were significant decreases in total body fat (-19.3%±9.6%), total fat-free mass (-2.7%±4.3%), and % body fat (-10.1%±7.5%), whereas % skeletal muscle significantly increased (8.9%±7.2%). In stepwise multiple linear regression analysis with change in HOMA-IR as the dependent variable, the change in % skeletal muscle was identified as an independent predictor (β=-0.280, R²=0.068, P<0.01).
conclusionImprovement of insulin resistance in female obese patients requires maintenance of skeletal muscle mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.