ArticleAllergy, asthma & immunology research2016
No Concentration Decrease of House Dust Mite Allergens With Rising Altitude in Alpine Regions.
Article in Allergy, asthma & immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Is altitude a determinant of the health benefits of nature exposure? A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- An unusually high prevalence of allergic rhinitis at high altitudes in 6-7 year old children - An epidemiological study.The World Allergy Organization journal · 2024Article
- Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort.The World Allergy Organization journal · 2023Article
- Response to high-altitude triggers in seasonal asthmatics on and off inhaled corticosteroid treatment.The World Allergy Organization journal · 2022Article
- Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper.Allergy · 2022Article
- Secondary and Tertiary Prevention: Medical Rehabilitation.Handbook of experimental pharmacology · 2022Article
- Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study.Environmental science and pollution research international · 2020Article
- House Dust Mite Allergy Under Changing Environments.Allergy, asthma & immunology research · 2019Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSeveral studies over the past 4 decades have indicated a significant reduction in house dust mite (HDM) and HDM allergen concentration in areas higher than 1,500 m above sea level. These have served as basis of allergen avoidance therapies for HDM allergy and asthma. However, modern construction techniques used in the insulation, heating, and glazing of buildings as well as global warming have changed the environmental parameters for HDM living conditions. The present study revisits the paradigm of decreasing HDM allergen concentrations with increasing altitude in the alpine region of Germany and Austria.
methodsA total of 122 dust samples from different abodes (hotels, privates and mountain huts) at different altitudes (400-2,600 m) were taken, and concentrations of HDM allergens were analyzed. Humidity and temperature conditions, and numerous indoor environmental parameters such as fine dust, type of flooring, age of building, and frequency of cleaning were determined.
resultsHDM allergen concentrations did not significantly change with increasing altitude or relative humidity. At the level of indoor parameters, correlations could be found for different flooring types and the concentration of HDM allergens.
conclusionsIn contrast to the widespread view of the relationship between altitude and HDM allergen concentrations, clinically relevant concentrations of HDM allergens could be detected in high-lying alpine regions in Austria and Germany. These results indicate that improvement in conditions of asthmatic patients sensitized against HDMs during a stay at high altitude can no longer be ascribed to decreased levels of HDM allergens, instead, other mechanisms may trigger the beneficial effect.
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