ArticleAddiction biology2017
Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study.
Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies.Drug and alcohol dependence · 2022Pooled it
- Common abnormality of gray matter integrity in substance use disorder and obsessive-compulsive disorder: A comparative voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- A meta-analysis of tract-based spatial statistics studies examining white matter integrity in cocaine use disorder.Addiction biology · 2021Pooled it
- Risky decision-making in individuals with substance use disorder: A meta-analysis and meta-regression review.Psychopharmacology · 2020Pooled it
- Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024Article
- Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment.Drug and alcohol dependence reports · 2024Article
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.The American journal of drug and alcohol abuse · 2024Article
- Neurovascular effects of cocaine: relevance to addiction.Frontiers in pharmacology · 2024Review
- A Longitudinal Investigation of Blood Neurofilament Light Chain Levels in Chronic Cocaine Users.Molecular neurobiology · 2023Article
- Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders.Brain : a journal of neurology · 2023Article
- Recovery of inhibitory control prefrontal cortex function in inpatients with heroin use disorder: a 15-week longitudinal fMRI study.medRxiv : the preprint server for health sciences · 2023Article
- Transcranial Stimulation for the Treatment of Stimulant Use Disorder.Neurology international · 2023Review
- Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use.Molecular psychiatry · 2023Article
- Residual deficits in functional brain activity after chronic cocaine self-administration in rhesus monkeys.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Partial recovery of the left DLPFC-right insula circuit with reduced craving in abstinent heroin users: a longitudinal study.Brain imaging and behavior · 2022Article
- Effects of Human Immunodeficiency Virus Infection and Former Cocaine Dependence on Neuroanatomical Measures and Neurocognitive Performance.Neuroscience · 2022Article
- Recovery of superior frontal gyrus cortical thickness and resting-state functional connectivity in abstinent heroin users after 8 months of follow-up.Human brain mapping · 2022Article
- Emotion recognition in individuals with cocaine use disorder: the role of abstinence length and the social brain network.Psychopharmacology · 2022Article
- Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing.Brain communications · 2022Article
- Common and gender-specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Deficits in prefrontal cortical (PFC) function have been consistently reported in individuals with cocaine use disorders (iCUD), and have separately been shown to improve with longer-term abstinence. However, it is less clear whether the PFC structural integrity possibly underlying these deficits is also modulated by sustained reduction in drug use in iCUD. Here, T1-weighted magnetic resonance imaging scans were acquired, and performance on a neuropsychological test battery was assessed, in 19 initially abstinent treatment-seeking iCUD, first at baseline and then after six months of significantly reduced or no drug use (follow-up). A comparison cohort of 12 healthy controls was also scanned twice with a similar inter-scan interval. The iCUD showed increased gray matter volume in the left inferior frontal gyrus and bilaterally in the ventromedial prefrontal cortex at follow-up compared to baseline; healthy controls, as expected, showed no changes over this same time period. The iCUD also showed improved decision making and cognitive flexibility, with the latter correlated significantly with the gray matter volume increases in the inferior frontal gyrus. Given its association with improved cognitive function, the longitudinal recovery in cortical gray matter volume, particularly in regions where structure and function are adversely affected by chronic drug use, reflects a quantifiable positive impact of significantly reduced drug use on cortical structural integrity.
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Registered trials
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