ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2016
Emergence of community-associated methicillin-resistant Staphylococcus aureus strains in the neonatal intensive care unit: an infection prevention and patient safety challenge.
Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Neonatal Sepsis: Etiology, Antimicrobial Susceptibility, and Treatment Outcomes in a Tertiary Hospital in Jos, Nigeria.The American journal of tropical medicine and hygiene · 2026Article
- Colonization with antiseptic tolerantInfection control and hospital epidemiology · 2025Article
- The Influence of Maternal Staphylococcus aureus Anti-Hla Neutralizing Antibody on Infant Skin and Soft Tissue Development in the First Year of Life.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Molecular Epidemiology Clinical Manifestations, Decolonization Strategies, and Treatment Options of Methicillin-ResistantPathogens (Basel, Switzerland) · 2025Review
- Impact of methicillin-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit.Open forum infectious diseases · 2024Article
- Healthcare worker perceptions surroundingInfection control and hospital epidemiology · 2023Article
- Clinical characteristics and antibiotic resistance profile of invasive MRSA infections in newborn inpatients: a retrospective multicenter study from China.BMC pediatrics · 2023Article
- A 30-Day-Old Infant with Necrotizing Fasciitis of the Perineal Region Involving the Scrotum Due to Methicillin-Resistant Staphylococcus aureus (MRSA) and Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae: A Case Report.The American journal of case reports · 2022Article
- Inanimate Surfaces and Air Contamination with Multidrug Resistant Species ofMicroorganisms · 2022Article
- Risk Factors Associated with Methicillin Resistance in Hospitalized Newborn Infants withInfection and drug resistance · 2022Article
- Antimicrobial stewardship of antiseptics that are pertinent to wounds: the need for a united approach.JAC-antimicrobial resistance · 2021Review
- Molecular epidemiology of antimicrobial resistant microorganisms in the 21th century: a review of the literature.Acta bio-medica : Atenei Parmensis · 2020Review
- Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia.Antimicrobial resistance and infection control · 2020Article
- The prevalence of antiseptic tolerance genes among staphylococci and enterococci in a pediatric population.Infection control and hospital epidemiology · 2019Article
- Prevalence and characteristics of methicillin-resistantJournal of general and family medicine · 2018Article
- Manipulating the microbiome: evolution of a strategy to prevent S. aureus disease in children.Journal of perinatology : official journal of the California Perinatal Association · 2018Review
- New Threats from an Old Foe: Methicillin-Resistant Staphylococcus aureus Infections in Neonates.Neonatology · 2018Review
- A prospective cohort study ofInfection and drug resistance · 2018Article
- Accurate Detection of Methicillin-Resistant Staphylococcus aureus in Mixtures by Use of Single-Bacterium Duplex Droplet Digital PCR.Journal of clinical microbiology · 2017Article
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Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) infections cause significant morbidity and mortality in neonatal intensive care units (NICUs). We characterized the clinical and molecular epidemiology of MRSA strains colonizing NICU patients. Nasal MRSA isolates (n = 250, from 96 NICU patients) recovered through active surveillance from 2009 to 2014 were characterized with staphylococcal cassette chromosome mec (SCCmec) typing and detection of mupA (marker of high-level mupirocin resistance) and qacA/B (marker associated with chlorhexidine resistance). Factors associated with community-associated (CA-) or healthcare-associated (HA-) MRSA were evaluated. The overall prevalence of MRSA nasal colonization was 3.9%. Of 96 neonates in our retrospective cohort, 60 (63%) were colonized with CA-MRSA strains and 35 (36%) were colonized with HA-MRSA strains. Patients colonized with HA-MRSA were more likely to develop MRSA infections than patients colonized with CA-MRSA (13/35, 37% versus 8/60, 13%; p 0.007), although the interval from colonization to infection was shorter in CA-MRSA-colonized infants (median 0 days, range -1 to 4 versus HA-MRSA-colonized infants, 7 days, -1 to 43; p 0.005). Maternal peripartum antibiotics were associated with CA-MRSA colonization (adjusted odds ratio (aOR) 8.7; 95% CI 1.7-45.0); intubation and surgical procedures were associated with HA-MRSA colonization (aOR 7.8; 95% CI 1.3-47.6 and aOR 6.0; 95% CI 1.4-24.4, respectively). Mupirocin- and chlorhexidine-resistant MRSA was isolated from four and eight patients, respectively; carriage of a mupirocin-resistant strain precluded decolonization. CA-MRSA strains are prominent in the NICU and associated with distinct risk factors. Given community reservoirs for MRSA acquisition and transmission, novel infection prevention strategies are needed.
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