ArticleJournal of the American Heart Association2016
Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Indoor and outdoor air pollution and couple fecundability: a systematic review.Human reproduction update · 2023Pooled it
- Acute Effects of Particulate Matter on All-Cause Mortality in Urban, Rural, and Suburban Areas, Italy.International journal of environmental research and public health · 2021Pooled it
- Effects of prenatal exposure to NOEnvironmental science and pollution research international · 2020Pooled it
- Exposure timing is a determinant of fine particulate matter (PM2.5) pulmonary, vascular, and metabolic toxicity in male mice.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- The impact of mixed exposure to PMFrontiers in public health · 2026Article
- Association of PM2.5 exposure with 10-year atherosclerotic cardiovascular disease risk: a mediation analysis of blood and urinary biomarkers.Frontiers in public health · 2026Article
- Joint impacts of air pollution and healthy lifestyles on kidney function decline: insights from a nationwide cohort study.Renal failure · 2025Article
- Association between outdoor and indoor air pollutant exposure and depression among middle-aged and older adults in China.Scientific reports · 2025Article
- Prenatal ozone exposure and child lung function: Exploring effect modification by oxidative balance score.International journal of hygiene and environmental health · 2025Article
- Association between annual concentration of air pollutants and incidence of metabolic syndrome among Korean adults: Korean Genome and Epidemiology Study (KoGES).Environmental health : a global access science source · 2025Article
- Potential causal associations of long-term exposure to PMEcotoxicology and environmental safety · 2025Article
- Toward the application of metallothionein inducers as a method of prevention of air pollutant-dependent lung injury.Frontiers in public health · 2025Article
- Association between household solid fuel use and dual sensory impairment in a Chinese population: a retrospective cohort study.Frontiers in public health · 2025Article
- Ambient Air Pollution and Hospitalizations for Schizophrenia in China.JAMA network open · 2024Article
- Associations between Changes in Exposure to Air Pollutants due to Relocation and the Incidence of 14 Major Disease Categories and All-Cause Mortality: A Natural Experiment Study.Environmental health perspectives · 2024Article
- Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Effects of ambient air pollution on the hospitalization risk and economic burden of mental disorders in Qingdao, China.International archives of occupational and environmental health · 2024Article
- Ambient fine particulate matter chemical composition associated with in-hospital case fatality, hospital expenses, and length of hospital stay among patients with heart failure in China.Journal of global health · 2024Article
- Association between prenatal and childhood PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024Article
- Association between short-term exposure to ambient air pollutants and biomarkers indicative of inflammation and oxidative stress: a cross-sectional study using KoGES-HEXA data.Environmental health and preventive medicine · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundShort-term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism. However, few community-based studies have assessed this association. METHODS AND
resultsTwo thousand thirty-five Framingham Offspring Cohort participants living within 50 km of the Harvard Boston Supersite who were not current smokers were included. We assessed circulating biomarkers of oxidative stress including blood myeloperoxidase at the seventh examination (1998-2001) and urinary creatinine-indexed 8-epi-prostaglandin F2α (8-epi-PGF2α) at the seventh and eighth (2005-2008) examinations. We measured fine particulate matter (PM2.5), black carbon, sulfate, nitrogen oxides, and ozone at the Supersite and calculated 1-, 2-, 3-, 5-, and 7-day moving averages of each pollutant. Measured myeloperoxidase and 8-epi-PGF2α were loge transformed. We used linear regression models and linear mixed-effects models with random intercepts for myeloperoxidase and indexed 8-epi-PGF2α, respectively. Models were adjusted for demographic variables, individual- and area-level measures of socioeconomic position, clinical and lifestyle factors, weather, and temporal trend. We found positive associations of PM2.5 and black carbon with myeloperoxidase across multiple moving averages. Additionally, 2- to 7-day moving averages of PM2.5 and sulfate were consistently positively associated with 8-epi-PGF2α. Stronger positive associations of black carbon and sulfate with myeloperoxidase were observed among participants with diabetes than in those without.
conclusionsOur community-based investigation supports an association of select markers of ambient air pollution with circulating biomarkers of oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.