Evidence map›Paper›PMID 27126387›Full record

ArticleClinical endoscopy2017

Association between Type of Sedation and the Adverse Events Associated with Gastrointestinal Endoscopy: An Analysis of 5 Years' Data from a Tertiary Center in the USA.

Basavana Goudra, Ahmad Nuzat, Preet Mohinder Singh, Anuradha Borle, Augustus Carlin, Gowri Gouda

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06085859 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Anesthesia Endoscope Mask is Applied to Sedation Upper Gastrointestinal Endoscopic Diagnosis and Treatment: Multi-center, Prospective, Randomized Control, Open Clinical Research

TypeinterventionalSponsorSichuan Provincial People's HospitalRan2023 to 2023Enrolled1,208ConditionsHypoxemiaArmsRoutine nasal catheter group, Mask group
NCT06111872 phase2completednot on this mapstarted 2023, after this paper: background citation

Combination Use of Intravenous Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography ; A Randomized Control Trial

TypeinterventionalSponsorNational University of MalaysiaRan2023 to 2024Enrolled90ConditionsCholangitis, Pancreatic Cancer, Choledocholithiasis, Choledochal CystArmsKetamine, Midazolam, Pethidin
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. No increased risk of perforation during colonoscopy in patients undergoing propofol versus traditional sedation: A meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018
    Pooled it
  3. Safety of non-anesthesia provider administered propofol sedation in non-advanced gastrointestinal endoscopic procedures: A meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
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  15. Just a touch of propofol for the colonoscopy: should the anesthesiologist be concerned?Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Basavana GoudraDepartment of Clinical Anesthesiology and Critical Care, Perelman School of Medicine, Philadelphia, PA, USA.
Ahmad NuzatDepartment of Endoscopy, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia, PA, USA.
Preet Mohinder SinghDepartment of Anesthesiology and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi, India.
Anuradha BorleDepartment of Anesthesia, All India Institute of Medical Sciences, New Delhi, India.
Augustus CarlinDepartment of Clinical Anesthesiology and Critical Care, Perelman School of Medicine, Philadelphia, PA, USA.
Gowri GoudaDepartment of Clinical Anesthesiology and Critical Care, Perelman School of Medicine, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe landscape of sedation for gastrointestinal (GI) endoscopic procedures and the nature of the procedures themselves have changed over the last decade. In this study, an attempt is made to analyze the frequency and etiology of all major adverse events associated with GI endoscopy.

methodsAll adverse events extracted from the electronic database and local registry were analyzed. Although the data analysis was retrospective, the adverse events themselves were documented prospectively. These events were evaluated after subdivision into propofol-based anesthesia and intravenous conscious sedation groups.

resultsCardiorespiratory events, including cardiac arrest, were the most common adverse events during esophagogastroduodenoscopy, while bleeding was more frequent in patients undergoing colonoscopy. Pancreatitis was the most frequent adverse event in patients undergoing endoscopic retrograde cholangiopancreatography. The frequencies of most adverse events were significantly higher in patients anesthetized with propofol. Automatic regression modeling showed that the type of sedation, the American Society of Anesthesiologists physical status classification, and the procedure type were some of the predictors of immediate life-threatening complications.

conclusionsClearly, our regression modeling suggests a strong association between the type of sedation as well as various patient factors and the frequency of adverse events. The possible reasons for our results are the changing demographics, the worsening comorbidities of the patient population, and the increasing technical complexity of these procedures. Although extensive use of propofol has increased patient satisfaction and procedure acceptability, its use is also associated with more frequent adverse events.

Indexed as

Cholangiopancreatography, endoscopic retrogradeColonoscopyEndoscopyMorbidityPropofol

Identifiers

PMID27126387
PMCPMC5398365

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.