Evidence map›Paper›PMID 27126384›Full record

ReviewCurrent genetics2016

Phenotypic heterogeneity in a bacteriophage population only appears as stress-induced mutagenesis.

Ido Yosef, Rotem Edgar, Udi Qimron

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ido YosefDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Rotem EdgarDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Udi QimronDepartment of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel. ehudq@post.tau.ac.il.
Tel Aviv University · IL

Funding

European Research Council 336079
6 · The paper itself

Abstract

Stress-induced mutagenesis has been studied in cancer cells, yeast, bacteria, and archaea, but not in viruses. In a recent publication, we present a bacteriophage model showing an apparent stress-induced mutagenesis. We show that the stress does not drive the mutagenesis, but only selects the fittest mutants. The mechanism underlying the observed phenomenon is a phenotypic heterogeneity that resembles persistence of the viral population. The new findings, the background for the ongoing debate on stress-induced mutagenesis, and the phenotypic heterogeneity underlying a novel phage infection strategy are discussed in this short manuscript.

Indexed as

Gene-Environment InteractionMutagenesisPhenotypeStress, PhysiologicalBacteriaBacteriophagesSelection, GeneticCryptic growthDarwinLamarckNatural selectionPhage resistance

Identifiers

PMID27126384
OpenAlexW2343899206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.