ArticleScientific reports2016
Potential pathways by which maternal second-hand smoke exposure during pregnancy causes full-term low birth weight.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Chemical Components in the Breast Milk of Passive Smoker Women: A Systematic Review and Health Risks Assessment.Biological trace element research · 2025Pooled it
- Secondhand Smoke Exposure Timing Triggers Distinct Placental Responses in Mouse Pregnancy.Cells · 2025Article
- Potentially toxic metals in umbilical cord blood as a biomarker for passive smoker women.Scientific reports · 2025Article
- Article
- Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation.Environment & health (Washington, D.C.) · 2024Article
- A Comparison of Measured Airborne and Self-Reported Secondhand Smoke Exposure in the MADRES Pregnancy Cohort Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- The mediation effect of placental weight change in the association between prenatal exposure to selenium and birth weight: Evidence from a prospective birth cohort study in China.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study.Frontiers in public health · 2021Article
- Low birthweight of children is positively associated with mother's prenatal tobacco smoke exposure in Shanghai: a cross-sectional study.BMC pregnancy and childbirth · 2020Observational
- Socioeconomic characteristics, paternal smoking and secondhand tobacco smoke exposure among infants in Jakarta, Indonesia.Tobacco induced diseases · 2020Article
- The association between secondhand smoke exposure and growth outcomes of children: A systematic literature review.Tobacco induced diseases · 2020Review
- Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice.Scientific reports · 2017Article
- Secondhand Smoke Exposure during Pregnancy and its Effect on Birth Outcomes: Evidence from a Retrospective Cohort Study in a Tertiary Care Hospital in Bengaluru.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well documented that maternal exposure to second-hand smoke (SHS) during pregnancy causes low birth weight (LBW), but its mechanism remains unknown. This study explored the potential pathways. We enrolled 195 pregnant women who delivered full-term LBW newborns, and 195 who delivered full-term normal birth weight newborns as the controls. After controlling for maternal age, education level, family income, pre-pregnant body mass index, newborn gender and gestational age, logistic regression analysis revealed that LBW was significantly and positively associated with maternal exposure to SHS during pregnancy, lower placental weight, TNF-α and IL-1β, and that SHS exposure was significantly associated with lower placental weight, TNF-α and IL-1β. Structural equation modelling identified two plausible pathways by which maternal exposure to SHS during pregnancy might cause LBW. First, SHS exposure induced the elevation of TNF-α, which might directly increase the risk of LBW by transmission across the placenta. Second, SHS exposure first increased maternal secretion of IL-1β and TNF-α, which then triggered the secretion of VCAM-1; both TNF-α and VCAM-1 were significantly associated with lower placental weight, thus increasing the risk of LBW. In conclusion, maternal exposure to SHS during pregnancy may lead to LBW through the potential pathways of maternal inflammation and lower placental weight.
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