Evidence map›Paper›PMID 27126100›Full record

ReviewSeminars in immunopathology2016

Transcriptional regulation of mast cell and basophil lineage commitment.

Hua Huang, Yapeng Li, Bing Liu

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  15. A human cell atlas of fetal gene expression.Science (New York, N.Y.) · 2020
    Article
  16. Article
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  18. [Key transcription factors in myeloid hematopoiesis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019
    Article
  19. Article
  20. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis.The Journal of allergy and clinical immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Hua HuangDepartment of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA. huangh@njhealth.org.
Yapeng LiDepartment of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.
Bing LiuDepartment of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA.
University of Colorado Denver · USZhongnan Hospital of Wuhan University · CN

Funding

Innate Effectors and Type-2 InflammationR01AI107022 · NIAID · NATIONAL JEWISH HEALTH · PI HUANG, HUA · 2016 to 2020
$2.0M
Gene Responses in Basophil-Mediated Allergic ResponsesR01AI083986 · NIAID · NATIONAL JEWISH HEALTH · PI HUANG, HUA · 2010 to 2014
$1.9M
NIAID NIH HHS R01 AI083986NIAID NIH HHS R01 AI107022
6 · The paper itself

Abstract

Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances in the understanding of origin and molecular regulation of mouse and human basophil and mast cell development. A more complete understanding of how basophils and mast cells develop at the molecular level will lead to development of interventions that are more effective in achieving long-term success.

Indexed as

Gene Expression RegulationTranscription, GeneticAnimalsBasophilsCCAAT-Enhancer-Binding ProteinsCell DifferentiationCell LineageGranulocyte-Macrophage Progenitor CellsHematopoiesisHumansMast CellsMiceMicrophthalmia-Associated Transcription FactorOrgan SpecificityProtein BindingTranscription FactorsCCAAT-Enhancer-Binding ProteinsMicrophthalmia-Associated Transcription FactorTranscription FactorsBasophilsBi-potential basophil/mast cell progenitorsLineage commitmentMast cells

Identifiers

PMID27126100
PMCPMC5010465
OpenAlexW2344885910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.