ArticleScience (New York, N.Y.)2016
Kinetically controlled E-selective catalytic olefin metathesis.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 134 citations in OpenAlex.
- Decarboxylative alkylation of alkenes.Nature · 2026Article
- Synthetic methodologies for the chemical recycling of fluorocarbons.Nature reviews. Chemistry · 2026Review
- Synthesis and applications of alkenyl chlorides (vinyl chlorides): a review.Beilstein journal of organic chemistry · 2026Review
- Aromatic Amide Foldamers Show Conformation-Dependent Electronic Properties.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Stereoselective Copper-Catalyzed Olefination of Imines.Angewandte Chemie (International ed. in English) · 2024Article
- Practical Synthesis of Terminal Vinyl Fluorides.The Journal of organic chemistry · 2023Article
- Article
- Fluorescent organometallic dyads and triads: establishing spatial relationships.Chemical science · 2023Article
- E- and Z-trisubstituted macrocyclic alkenes for natural product synthesis and skeletal editing.Nature chemistry · 2022Article
- Stereodefined alkenes with a fluoro-chloro terminus as a uniquely enabling compound class.Nature chemistry · 2022Article
- The Ascent of Alkyne Metathesis to Strategy-Level Status.Journal of the American Chemical Society · 2021Article
- Air-stable 18-electron adducts of Schrock catalysts with tuned stability constants for spontaneous release of the active species.Communications chemistry · 2021Article
- A donor-acceptor complex enables the synthesis ofChemical science · 2021Article
- Olefin metathesis: what have we learned about homogeneous and heterogeneous catalysts from surface organometallic chemistry?Chemical science · 2021Review
- Cobalt-CatalyzedACS omega · 2020Article
- Regio- and Stereoselective Thianthrenation of Olefins To Access Versatile Alkenyl Electrophiles.Angewandte Chemie (International ed. in English) · 2020Article
- Silver-catalyzed synthesis of β-fluorovinylphosphonates by phosphonofluorination of aromatic alkynes.Beilstein journal of organic chemistry · 2020Article
- E- and Z-, di- and tri-substituted alkenyl nitriles through catalytic cross-metathesis.Nature chemistry · 2019Article
- Traceless Protection for More Broadly Applicable Olefin Metathesis.Angewandte Chemie (International ed. in English) · 2019Article
- Tandem Catalysis: Transforming Alcohols to Alkenes by Oxidative Dehydroxymethylation.Journal of the American Chemical Society · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A major shortcoming in olefin metathesis, a chemical process that is central to research in several branches of chemistry, is the lack of efficient methods that kinetically favor E isomers in the product distribution. Here we show that kinetically E-selective cross-metathesis reactions may be designed to generate thermodynamically disfavored alkenyl chlorides and fluorides in high yield and with exceptional stereoselectivity. With 1.0 to 5.0 mole % of a molybdenum-based catalyst, which may be delivered in the form of air- and moisture-stable paraffin pellets, reactions typically proceed to completion within 4 hours at ambient temperature. Many isomerically pure E-alkenyl chlorides, applicable to catalytic cross-coupling transformations and found in biologically active entities, thus become easily and directly accessible. Similarly, E-alkenyl fluorides can be synthesized from simpler compounds or more complex molecules.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.