ArticleRespiratory physiology & neurobiology2016
The course of lung inflation alters the central pattern of tracheobronchial cough in cat-The evidence for volume feedback during cough.
Article in Respiratory physiology & neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology.International journal of environmental research and public health · 2022Review
- Influence of intrathoracic vagotomy on the cough reflex in the anesthetized cat.Respiratory physiology & neurobiology · 2022Article
- Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.PloS one · 2021Article
- Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat.Physiological research · 2020Article
- GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.Respiratory physiology & neurobiology · 2018Article
- Strategies for the Integration of Cough and Swallow to Maintain Airway Protection in Humans.Lung · 2018Article
- Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough.Journal of neurophysiology · 2017Article
- Cough modulation by upper airway stimuli in cat - potential clinical application?Open journal of molecular and integrative physiology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
The effect of volume-related feedback and output airflow resistance on the cough motor pattern was studied in 17 pentobarbital anesthetized spontaneously-breathing cats. Lung inflation during tracheobronchial cough was ventilator controlled and triggered by the diaphragm electromyographic (EMG) signal. Altered lung inflations during cough resulted in modified cough motor drive and temporal features of coughing. When tidal volume was delivered (via the ventilator) there was a significant increase in the inspiratory and expiratory cough drive (esophageal pressures and EMG amplitudes), inspiratory phase duration (CTI), total cough cycle duration, and the duration of all cough related EMGs (Tactive). When the cough volume was delivered (via the ventilator) during the first half of inspiratory period (at CTI/2-early over inflation), there was a significant reduction in the inspiratory and expiratory EMG amplitude, peak inspiratory esophageal pressure, CTI, and the overlap between inspiratory and expiratory EMG activity. Additionally, there was significant increase in the interval between the maximum inspiratory and expiratory EMG activity and the active portion of the expiratory phase (CTE1). Control inflations coughs and control coughs with additional expiratory resistance had increased maximum expiratory esophageal pressure and prolonged CTE1, the duration of cough abdominal activity, and Tactive. There was no significant difference in control coughing and/or control coughing when sham ventilation was employed. In conclusion, modified lung inflations during coughing and/or additional expiratory airflow resistance altered the spatio-temporal features of cough motor pattern via the volume related feedback mechanism similar to that in breathing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.