ArticleThe Journal of pathology2016
Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori.
Article in The Journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Disrupting SRSF10-dependent BCAT2 exon skipping reprograms tumor-associated macrophages and enhances anti-PD-1 efficacy in gastric cancer.Cell death & disease · 2026Article
- Recent advances in spasmolytic polypeptide expressing metaplasia research.World journal of gastrointestinal oncology · 2026Review
- Revolutionizing Gastric Cancer Prevention: Novel Insights on Gastric Mucosal Inflammation-Cancer Transformation and Chinese Medicine.Chinese journal of integrative medicine · 2025Review
- Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine.Journal of molecular cell biology · 2024Article
- R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.The Journal of clinical investigation · 2022Article
- Animal Models andJournal of clinical medicine · 2022Review
- Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.Gastroenterology · 2022Review
- Global knowledge mapping and emerging trends in research between spasmolytic polypeptide-expressing metaplasia and gastric carcinogenesis: A bibliometric analysis from 2002 to 2022.Frontiers in cellular and infection microbiology · 2022Article
- Genetic Pathogenesis of Inflammation-Associated Cancers in Digestive Organs.Pathogens (Basel, Switzerland) · 2021Review
- DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia.Gastroenterology · 2021Article
- Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia's Pattern of Spread Throughout the Stomach.Frontiers in cell and developmental biology · 2021Review
- Caudal type homeoboxes as a driving force inGut microbes · 2020Article
- Premalignant lesions and gastric cancer: Current understanding.World journal of gastrointestinal oncology · 2019Review
- MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils.Gastroenterology · 2019Article
- CarcinogenicMolecular & cellular proteomics : MCP · 2019Article
- Evaluation of Lineage Changes in the Gastric Mucosa Following Infection WithThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- The role of Clusterin in cancer metastasis.Cancer management and research · 2019Article
- Subtle Protective Roles of Clusterin in Gastric Metaplasia After Acute Oxyntic Atrophy.Cellular and molecular gastroenterology and hepatology · 2019Article
- Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection.Cellular and molecular gastroenterology and hepatology · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia are considered neoplastic precursors of gastric adenocarcinoma in humans. Loss of parietal cells causes the development of SPEM in the gastric corpus and then chronic inflammation drives SPEM toward a more proliferative lineage. Mongolian gerbils infected with Helicobacter pylori develop chronic gastritis and metaplasia, mimicking aspects of human gastritis with H. pylori infection. We therefore examined metaplastic lineages in the gastric corpus mucosa of gerbils infected by H. pylori strain 7.13, which produces rapid onset of severe inflammation. Six weeks following H. pylori infection, Griffonia simplicifolia lectin II (GSII)-positive SPEM developed in the base of oxyntic glands in association with parietal cell loss and inflammation. In association with severe inflammation, SPEM glands evolved into aberrant phenotypes, including branched lesions, dilated lesions, and penetrating invasive glands. Mucin 4 (MUC4) was up-regulated in SPEM and progressive SPEM. Clusterin was expressed in the tips of branched and dilated lesions and throughout regions of invasive glands. Intriguingly, clusterin-positive regions in these lesions expressed Ki67 and matrix metalloproteinase 7 (MMP-7). These same regions were also positive for expression of phospho-IkBα, suggestive of activated NFkB signalling. These findings suggest that clusterin-positive regions in progressive phenotypes of SPEM have invasive characteristics. Thus, H. pylori infection in gerbils induces SPEM, which then can progress to further aberrant and invasive metaplastic phenotypes. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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