Evidence map›Paper›PMID 27125910›Full record

ArticleNature communications2016

Ultraflexible organic amplifier with biocompatible gel electrodes.

Tsuyoshi Sekitani, Tomoyuki Yokota, Kazunori Kuribara, Martin Kaltenbrunner, Takanori Fukushima, Yusuke Inoue, Masaki Sekino, Takashi Isoyama, Yusuke Abe, Hiroshi Onodera and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Ionic Conductive Textiles for Wearable Technology.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  11. Gel-Based Ionic Circuits.Chemical reviews · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tsuyoshi SekitaniDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.
Tomoyuki YokotaDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.ORCID http://orcid.org/0000-0003-1546-8864
Kazunori KuribaraDepartment of Applied Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Martin KaltenbrunnerDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.ORCID http://orcid.org/0000-0002-7247-9183
Takanori FukushimaChemical Resource Laboratory, Tokyo Institute of Technology, 4259R1-1, Nagatsuda, Midoriku, Yokohama, Kanagawa 226-8503, Japan.
Yusuke InoueDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.
Masaki SekinoDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.
Takashi IsoyamaDepartment of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Yusuke AbeDepartment of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Hiroshi OnoderaDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.
Takao SomeyaDepartment of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8656, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel composite exhibits admittance of 100 mS cm(-2) and maintains high admittance even in a low-frequency range. On implantation into a living hypodermal tissue for 4 weeks, it showed a small foreign-body reaction compared with widely used metal electrodes. Capitalizing on the multi-functional gel composite, we fabricated an ultrathin and mechanically flexible organic active matrix amplifier on a 1.2-μm-thick polyethylene-naphthalate film to amplify (amplification factor: ∼200) weak biosignals. The composite was integrated to the amplifier to realize a direct lead epicardial electrocardiography that is easily spread over an uneven heart tissue.

Indexed as

AnimalsBiocompatible MaterialsCell LineCell SurvivalDermisElectrocardiographyElectrodesElectronicsFemaleFibroblastsForeign-Body ReactionGoatsHydrogelsMaleNanotubes, CarbonNaphthalenesBiocompatible MaterialsHydrogelsNanotubes, CarbonNaphthalenesPolyethylenes

Identifiers

PMID27125910
PMCPMC5411732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.