Evidence map›Paper›PMID 27125818›Full record

Trial reportEuropean child & adolescent psychiatry2016

Clinical characteristics associated with the prescribing of SSRI medication in adolescents with major unipolar depression.

Lesley Cousins, Kirstie J Whitaker, Barry Widmer, Nick Midgley, Sarah Byford, Bernadka Dubicka, Raphael Kelvin, Shirley Reynolds, Christopher Roberts, Fiona Holland and 6 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Lesley CousinsDevelopmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK.
Kirstie J WhitakerDevelopmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK.
Barry WidmerDevelopmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK.
Nick MidgleyAnna Freud Centre, University College London, London, UK.
Sarah ByfordCentre for the Economics of Mental and Physical Health, Kings College London, London, UK.
Bernadka DubickaInstitute of Brain and Behaviour and Mental Health, University of Manchester, Manchester, UK.
Raphael KelvinDevelopmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK.
Shirley ReynoldsSchool of Medicine, University of East Anglia, Norwich, UK.
Christopher RobertsBiostatistics Group, Institute of Population Health, University of Manchester, Manchester, UK.
Fiona HollandBiostatistics Group, Institute of Population Health, University of Manchester, Manchester, UK.
Barbara BarrettCentre for the Economics of Mental and Physical Health, Kings College London, London, UK.
Robert SeniorThe Tavistock and Portman NHS Foundation Trust, Tavistock Centre, London, UK.
Paul WilkinsonDevelopmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK.
Mary TargetAnna Freud Centre, University College London, London, UK.
Peter FonagyAnna Freud Centre, University College London, London, UK.
Ian M GoodyerDevelopmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK. ig104@cam.ac.uk.
University of Cambridge · GBKing's College London · GBUniversity College London · GBUniversity of Manchester · GBAnna Freud Centre · GBCambridgeshire and Peterborough NHS Foundation Trust · GBLancashire Care NHS Foundation Trust · GBThe Tavistock and Portman NHS Foundation Trust · GBUniversity of East Anglia · GB

Funding

Department of Health 06/05/01Department of Health 97/29/01
6 · The paper itself

Abstract

Unipolar major depressions (MD) emerge markedly during adolescence. National Institute for Health and Care Excellence (NICE) UK recommends psychological therapies, with accompanying selective serotonin reuptake inhibitors (SSRIs) prescribed in severe cases only. Here, we seek to determine the extent and rationale of SSRI prescribing in adolescent MD before entering a randomised clinical trial. SSRI prescribing, together with their clinical characteristics was determined in 465 adolescent patients with MD prior to receiving a standardised psychological therapy as part of the Improving mood with psychoanalytic and cognitive therapies (IMPACT) clinical trial. Overall, 88 (19 %) had been prescribed antidepressants prior to psychological treatment. The clinical correlates varied by gender: respectively, depression severity in boys and self-harming behaviours in girls. Prescribing also differed between clinical research centres. Medical practitioners consider severity of depression in boys as an indicator for antidepressant prescribing. Self-injury in girls appears to be utilised as a prescribing aid which is inconsistent with past and current revised UK NICE guidelines.

Indexed as

Drug PrescriptionsSeverity of Illness IndexAdolescentAntidepressive AgentsFemaleHumansMajor Depressive DisorderMaleSelective Serotonin Reuptake InhibitorsSelf-Injurious BehaviorSex CharacteristicsSurveys and QuestionnairesAntidepressive AgentsSelective Serotonin Reuptake InhibitorsAdolescentsAntidepressantsDepressionRiskSelf-harmSSRIs

Identifiers

PMID27125818
PMCPMC5102956
OpenAlexW2342923433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.