Trial reportHuman brain mapping2016
LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.
Trial report in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Neural mechanisms of psychedelic visual imagery.Molecular psychiatry · 2025Trial
- The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: effects on cognition.Psychopharmacology · 2018Trial
- Development and validation of an LC-MS/MS method to quantify lysergic acid diethylamide (LSD), iso-LSD, 2-oxo-3-hydroxy-LSD, and nor-LSD and identify novel metabolites in plasma samples in a controlled clinical trial.Journal of clinical laboratory analysis · 2018Trial
- Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects.Clinical pharmacokinetics · 2017Trial
- The science of psychedelic medicine.Nature medicine · 2026Review
- Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects.Current topics in behavioral neurosciences · 2026Review
- Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Mapping of Subjective Accounts into Interpreted Clusters (MOSAIC): Topic Modelling and LLM applied to Stroboscopic Phenomenology.Neuroscience of consciousness · 2026Article
- Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases.Schizophrenia bulletin · 2025Review
- LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Visual hallucinations induced by Ganzflicker and Ganzfeld differ in frequency, complexity, and content.Scientific reports · 2024Article
- Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences.Scientific reports · 2023Article
- The neural basis of psychedelic action.Nature neuroscience · 2022Review
- Human Cortical Serotonin 2A Receptor Occupancy by Psilocybin Measured Using [Frontiers in neuroergonomics · 2021Article
- Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders.Nature reviews. Neuroscience · 2020Review
- The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain.Scientific reports · 2020Article
- Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.NeuroImage · 2020Article
- Stochastic resonance model of synaesthesia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Research ethics aspects of experimentation with LSD on human subjects: a historical and ethical review.Medicine, health care, and philosophy · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The question of how spatially organized activity in the visual cortex behaves during eyes-closed, lysergic acid diethylamide (LSD)-induced "psychedelic imagery" (e.g., visions of geometric patterns and more complex phenomena) has never been empirically addressed, although it has been proposed that under psychedelics, with eyes-closed, the brain may function "as if" there is visual input when there is none. In this work, resting-state functional connectivity (RSFC) data was analyzed from 10 healthy subjects under the influence of LSD and, separately, placebo. It was suspected that eyes-closed psychedelic imagery might involve transient local retinotopic activation, of the sort typically associated with visual stimulation. To test this, it was hypothesized that, under LSD, patches of the visual cortex with congruent retinotopic representations would show greater RSFC than incongruent patches. Using a retinotopic localizer performed during a nondrug baseline condition, nonadjacent patches of V1 and V3 that represent the vertical or the horizontal meridians of the visual field were identified. Subsequently, RSFC between V1 and V3 was measured with respect to these a priori identified patches. Consistent with our prior hypothesis, the difference between RSFC of patches with congruent retinotopic specificity (horizontal-horizontal and vertical-vertical) and those with incongruent specificity (horizontal-vertical and vertical-horizontal) increased significantly under LSD relative to placebo, suggesting that activity within the visual cortex becomes more dependent on its intrinsic retinotopic organization in the drug condition. This result may indicate that under LSD, with eyes-closed, the early visual system behaves as if it were seeing spatially localized visual inputs. Hum Brain Mapp 37:3031-3040, 2016. © 2016 Wiley Periodicals, Inc.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.