ArticleScientific reports2016
Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
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- Zebrafish as a Model System for Brugada Syndrome.Reviews in cardiovascular medicine · 2024Review
- Zebrafish Congenital Heart Disease Models: Opportunities and Challenges.International journal of molecular sciences · 2024Review
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- Optical transparency and label-free vessel imaging of zebrafish larvae in shortwave infrared range as a tool for prolonged studying of cardiovascular system development.Scientific reports · 2022Article
- The Effect of Hypothermia and Osmotic Shock on the Electrocardiogram of Adult Zebrafish.Biology · 2022Article
- A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies.Biosensors & bioelectronics · 2022Article
- Simultaneous imaging of calcium and contraction in the beating heart of zebrafish larvae.Theranostics · 2022Article
- Kuoxin Decoction promotes lymphangiogenesis in zebrafish andFrontiers in pharmacology · 2022Article
- Influence of hypomagnetic field on the heartbeat in zebrafish embryos.Frontiers in physiology · 2022Article
- Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish.Disease models & mechanisms · 2021Article
- Adult zebrafish ventricular electrical gradients as tissue mechanisms of ECG patterns under baseline vs. oxidative stress.Cardiovascular research · 2021Article
- Zebrafish as a New Tool in Heart Preservation Research.Journal of cardiovascular development and disease · 2021Review
- Mechanisms ofJournal of cardiovascular development and disease · 2021Review
- Constructing Adult Zebrafish Einthoven's Triangle to Define Electrical Heart Axes.Frontiers in physiology · 2021Article
- An Overview of Methods for Cardiac Rhythm Detection in Zebrafish.Biomedicines · 2020Review
- Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adult zebrafish has been used to model the electrocardiogram (ECG) for human cardiovascular studies. Nonetheless huge variations are observed among studies probably because of the lack of a reliable and reproducible recording method. In our study, an adult zebrafish surface ECG recording technique was improved using a multi-electrode method and by pre-opening the pericardial sac. A convenient ECG data analysis method without wavelet transform was also established. Intraperitoneal injection of KCl in zebrafish induced an arrhythmia similar to that of humans, and the arrhythmia was partially rescued by calcium gluconate. Amputation and cryoinjury of the zebrafish heart induced ST segment depression and affected QRS duration after injury. Only cryoinjury decelerated the heart rate. Different changes were also observed in the QT interval during heart regeneration in these two injury models. We also characterized the electrocardiophysiology of breakdance zebrafish mutant with a prolonged QT interval, that has not been well described in previous studies. Our study provided a reliable and reproducible means to record zebrafish ECG and analyse data. The detailed characterization of the cardiac electrophysiology of zebrafish and its mutant revealed that the potential of the zebrafish in modeling the human cardiovascular system exceeds expectations.
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