ArticleScientific reports2016
In Vivo Mesoscopic Voltage-Sensitive Dye Imaging of Brain Activation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
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- Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomography.Journal of biomedical optics · 2020Article
- 3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Imaging stem cell distribution, growth, migration, and differentiation in 3-D scaffolds for bone tissue engineering using mesoscopic fluorescence tomography.Biotechnology and bioengineering · 2018Article
- Improving mesoscopic fluorescence molecular tomography through data reduction.Biomedical optics express · 2017Article
- High-dynamic-range fluorescence laminar optical tomography (HDR-FLOT).Biomedical optics express · 2017Article
- Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue.Journal of neuroscience methods · 2017Article
- Fluorescence laminar optical tomography for brain imaging: system implementation and performance evaluation.Journal of biomedical optics · 2017Article
- Review of mesoscopic optical tomography for depth-resolved imaging of hemodynamic changes and neural activities.Neurophotonics · 2017Review
- Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Functional mapping of brain activity is important in elucidating how neural networks operate in the living brain. The whisker sensory system of rodents is an excellent model to study peripherally evoked neural activity in the central nervous system. Each facial whisker is represented by discrete modules of neurons all along the pathway leading to the neocortex. These modules are called "barrels" in layer 4 of the primary somatosensory cortex. Their location (approximately 300-500 μm below cortical surface) allows for convenient imaging of whisker-evoked neural activity in vivo. Fluorescence laminar optical tomography (FLOT) provides depth-resolved fluorescence molecular information with an imaging depth of a few millimeters. Angled illumination and detection configurations can improve both resolution and penetration depth. We applied angled FLOT (aFLOT) to record 3D neural activities evoked in the whisker system of mice by deflection of a single whisker in vivo. A 100 μm capillary and a pair of microelectrodes were inserted to the mouse brain to test the capability of the imaging system. The results show that it is possible to obtain 3D functional maps of the sensory periphery in the brain. This approach can be broadly applicable to functional imaging of other brain structures.
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