ArticleScientific reports2016
High activity of the stress promoter contributes to susceptibility to stress in the tree shrew.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress.Journal of neuroendocrinology · 2026Article
- Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain.Zoological research · 2025Article
- Light at night negatively affects mood in diurnal primate-like tree shrews via a visual pathway related to the perihabenular nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.eNeuro · 2024Article
- Mediodorsal thalamus and ventral pallidum contribute to subcortical regulation of the default mode network.Communications biology · 2024Article
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
- Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators.Pharmacology & therapeutics · 2023Review
- Washed Microbiota Transplantation Accelerates the Recovery of Abnormal Changes by Light-Induced Stress in Tree Shrews.Frontiers in cellular and infection microbiology · 2021Article
- Social avoidance behavior in male tree shrews and prosocial behavior in male mice toward unfamiliar conspecifics in the laboratory.Zoological research · 2020Article
- The characteristics of gut microbiota and commensal Enterobacteriaceae isolates in tree shrew (Tupaia belangeri).BMC microbiology · 2019Article
- Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.Frontiers in neuroscience · 2019Article
- Transcriptional regulation of corticotropin-releasing hormone gene in stress response.IBRO reports · 2018Review
- Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse.Neuroscience bulletin · 2018Article
- Creating animal models, why not use the Chinese tree shrew (Zoological research · 2017Article
- Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring.Cell research · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress is increasingly present in everyday life in our fast-paced society and involved in the pathogenesis of many psychiatric diseases. Corticotrophin-releasing-hormone (CRH) plays a pivotal role in regulating the stress responses. The tree shrews are highly vulnerable to stress which makes them the promising animal models for studying stress responses. However, the mechanisms underlying their high stress-susceptibility remained unknown. Here we confirmed that cortisol was the dominate corticosteroid in tree shrew and was significantly increased after acute stress. Our study showed that the function of tree shrew CRH - hypothalamic-pituitary-adrenal (HPA) axis was nearly identical to human that contributed little to their hyper-responsiveness to stress. Using CRH transcriptional regulation analysis we discovered a peculiar active glucocorticoid receptor response element (aGRE) site within the tree shrew CRH promoter, which continued to recruit co-activators including SRC-1 (steroid receptor co-activator-1) to promote CRH transcription under basal or forskolin/dexamethasone treatment conditions. Basal CRH mRNA increased when the aGRE was knocked into the CRH promoter in human HeLa cells using CAS9/CRISPR. The aGRE functioned critically to form the "Stress promoter" that contributed to the higher CRH expression and susceptibility to stress. These findings implicated novel molecular bases of the stress-related diseases in specific populations.
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