ArticlePloS one2016
Obesity and Mortality, Length of Stay and Hospital Cost among Patients with Sepsis: A Nationwide Inpatient Retrospective Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis.BMC anesthesiology · 2017Pooled it
- Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study.PLoS medicine · 2020Trial
- The prognostic value of CT-quantified visceral and subcutaneous fat areas in sepsis.World journal of emergency medicine · 2026Article
- Do Obesity Classifications Create the Obesity Paradox? A Scoping Review of Obesity Definitions Applied in Sepsis Research.Clinical obesity · 2026Article
- Endotoxin retention in adipose tissue leading to persistent hypotension in catecholamine-dependent acute obstructive suppurative cholangitis.Journal of translational internal medicine · 2025Article
- Association of Obesity and Body Composition and Hospitalization Risk with Infection in the CRIC Study.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Exploring dietitians' experiences caring for patients living with obesity in acute care: a qualitative study.International journal of obesity (2005) · 2025Article
- The Association of Body Mass Index and Waist Circumference with Sepsis-Related Mortality in South Korea.Diagnostics (Basel, Switzerland) · 2024Article
- Early Sepsis-Associated Acute Kidney Injury and Obesity.JAMA network open · 2024Article
- Impact of body mass index on mortality outcomes in intensive care patients with Staphylococcus aureus sepsis: A retrospective analysis.PloS one · 2024Article
- Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study.Annals of intensive care · 2023Article
- Exploring Overnutrition, Overweight, and Obesity in the Hospital Setting-A Point Prevalence Study.Nutrients · 2023Article
- Dihydrotestosterone, and Not Testosterone, Enhances the LPS-Induced Inflammatory Cytokine Gene Expression in Human Adipocytes.Biomedicines · 2023Article
- Article
- The Impact of Body Mass Index in Patients with Severe Burn Injury.European burn journal · 2022Article
- The impact of obesity in patients hospitalized with opioid/opiate overdose.Substance abuse · 2022Article
- Influence of Overweight and Obesity on Morbidity and Mortality among Hospitalized Patients in Sri Lanka: A Single-Center Analysis.Journal of obesity · 2022Article
- Obesity protects against sepsis-induced and norepinephrine-induced white adipose tissue browning.American journal of physiology. Endocrinology and metabolism · 2021Article
- Effect of Obesity on Clinical Failure of Patients Treated With β-Lactams.Open forum infectious diseases · 2021Article
- Impact of Body Mass Index on the Survival of Patients with Sepsis with Different Modified NUTRIC Scores.Nutrients · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of this study was to examine the association between obesity and all-cause mortality, length of stay and hospital cost among patients with sepsis 20 years of age or older. MATERIALS AND
methodsIt was a retrospective cohort study. The dataset was the Nationwide Inpatient Sample 2011, the largest publicly available all-payer inpatient care database in the United States. Hospitalizations of sepsis patients 20 years of age or older were included. All 25 primary and secondary diagnosis fields were screened to identify patients with sepsis using International Classification of Diseases, Ninth Revision, Clinical Modification codes. Obesity was the exposure of interest. It was one of the 29 standardized Elixhauser comorbidity measures and readily available in the dataset as a dichotomized variable. The outcome measures were all-cause in-hospital death, length of stay and hospital cost.
resultsAfter weighting, our sample projected to a population size of 1,763,000, providing an approximation for the number of hospital discharges of all sepsis patients 20 years of age or older in the US in 2011. The overall all-cause mortality rate was 14.8%, the median hospital length of stay was 7 days and the median hospital cost was $15,917. After adjustment, the all-cause mortality was lower (adjusted OR = 0.84; 95% CI = 0.81 to 0.88); the average hospital length of stay was longer (adjusted difference = 0.65 day; 95% CI = 0.44 to 0.86) and the hospital cost per stay was higher (adjusted difference = $2,927; 95% CI = $1,606 to $4,247) for obese sepsis patients as compared to non-obese ones.
conclusionWith this large and nationally representative sample of over 1,000 hospitals in the US, we found that obesity was significantly associated with a 16% decrease in the odds of dying among hospitalized sepsis patients; however it was also associated with greater duration and cost of hospitalization.
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