ArticleStress (Amsterdam, Netherlands)2016
Wheel running improves REM sleep and attenuates stress-induced flattening of diurnal rhythms in F344 rats.
Article in Stress (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Mapping the effects of exercise on cognition and physical function: a scoping review of rodent studies.Frontiers in physiology · 2026Pooled it
- Voluntary wheel running behavior is reduced by SARS-CoV-2 S1 administration and mitigates hypothalamic neuroinflammatory processes.Brain, behavior, & immunity - health · 2026Article
- Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation.CNS neuroscience & therapeutics · 2026Review
- Roles of sleep-related cardiovascular autonomic functions in voluntary-exercise-induced alleviation of hypertension in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels.The journal of pain · 2021Article
- The Moderating Effect of Physical Activity on the Relationship between Sleep and Emotional Distress and the Difference between Blacks and Whites: A Secondary Data Analysis Using the National Health Interview Survey from 2005-2015.International journal of environmental research and public health · 2021Article
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep.Scientific reports · 2020Article
- Voluntary Wheel Running: A Useful Rodent Model for Investigating the Mechanisms of Stress Robustness and Neural Circuits of Exercise Motivation.Current opinion in behavioral sciences · 2019Article
- Interactions between stress and physical activity on Alzheimer's disease pathology.Neurobiology of stress · 2018Review
- Sleep/Wake Disruption in a Mouse Model of BLOC-1 Deficiency.Frontiers in neuroscience · 2018Article
- Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior.Behavioural brain research · 2017Article
- Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder.Neural plasticity · 2017Review
- Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Regular physical activity produces resistance to the negative health consequences of stressor exposure. One way that exercise may confer stress resistance is by reducing the impact of stress on diurnal rhythms and sleep; disruptions of which contribute to stress-related disease including mood disorders. Given the link between diurnal rhythm disruptions and stress-related disorders and that exercise both promotes stress resistance and is a powerful non-photic biological entrainment cue, we tested if wheel running could reduce stress-induced disruptions of sleep/wake behavior and diurnal rhythms. Adult, male F344 rats with or without access to running wheels were instrumented for biotelemetric recording of diurnal rhythms of locomotor activity, heart rate, core body temperature (CBT), and sleep (i.e. REM, NREM, and WAKE) in the presence of a 12 h light/dark cycle. Following 6 weeks of sedentary or exercise conditions, rats were exposed to an acute stressor known to disrupt diurnal rhythms and produce behaviors associated with mood disorders. Prior to stressor exposure, exercise rats had higher CBT, more locomotor activity during the dark cycle, and greater %REM during the light cycle relative to sedentary rats. NREM and REM sleep were consolidated immediately following peak running to a greater extent in exercise, compared to sedentary rats. In response to stressor exposure, exercise rats expressed higher stress-induced hyperthermia than sedentary rats. Stressor exposure disrupted diurnal rhythms in sedentary rats; and wheel running reduced these effects. Improvements in sleep and reduced diurnal rhythm disruptions following stress could contribute to the health promoting and stress protective effects of exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.