ReviewOphthalmic plastic and reconstructive surgery
Embryologic and Fetal Development of the Human Eyelid.
Review in Ophthalmic plastic and reconstructive surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Retinal vascular development in an immature retina at 33-34 weeks postmenstrual age predicts retinopathy of prematurity.Scientific reports · 2020Trial
- Human Lacrimal Gland Gene Expression.PloS one · 2017Trial
- Failure to Fuse Shut Eyelids, a Novel Unique Sign in Affected Fetus with Homozygous PPP1R13L Pathogenic Variant-A Case Report and Review of the Literature.International journal of molecular sciences · 2026Review
- Ocular Manifestations and Pathological Features in Goldenhar Syndrome: A 10-Year Retrospective Study.Ophthalmology and therapy · 2025Article
- DNA methyltransferase 1 regulates epithelial cell functions in corneal and eyelid development.Molecular vision · 2025Article
- Mucosal immune responses toMarine life science & technology · 2024Article
- Autophagy and Exocytosis of Lipofuscin Into the Basolateral Extracellular Space of Human Retinal Pigment Epithelium From Fetal Development to Adolescence.Investigative ophthalmology & visual science · 2024Article
- Growth of muscles and nerves in the upper eyelid: a morphometrical and immunohistochemical study using term human fetuses.Surgical and radiologic anatomy : SRA · 2024Article
- Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity.Microbiome · 2024Article
- Tear film lipid layer and corneal oxygenation: a new function?Eye (London, England) · 2023Review
- Wnt/β-catenin signaling controls mouse eyelid growth by mediating epithelial-mesenchymal interactions.The ocular surface · 2023Article
- Molecular and Cellular Regulations in the Development of the Choroidal Circulation System.International journal of molecular sciences · 2023Review
- A Systematic Approach of the Intrauterine Morphogenesis of the Human Palpebral Apparatus.Organogenesis · 2022Article
- The Role of Ectodysplasin A on the Ocular Surface Homeostasis.International journal of molecular sciences · 2022Review
- The morphogenesis of the rabbit meibomian gland in relation to sex hormones: Immunohistochemical and transmission electron microscopy studies.BMC zoology · 2022Article
- Potential Risks of Corneal Refractive Surgery in Patients with Ectodermal Dysplasia.Ophthalmology and therapy · 2022Article
- NGS Analysis Confirms CommonInternational journal of molecular sciences · 2021Article
- Congenital Eyelid Anomalies: What General Physicians Need To Know.Oman medical journal · 2021Review
- Ocular manifestations of ectodermal dysplasia.Orphanet journal of rare diseases · 2021Article
- Association between gestational period and obesity in children with the use of dermatoglyphic traits: A preliminary study.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review the recent data about eyelid morphogenesis, and outline a timeline for eyelid development from the very early stages during embryonic life till final maturation of the eyelid late in fetal life.
methodsThe authors extensively review major studies detailing human embryologic and fetal eyelid morphogenesis. These studies span almost a century and include some more recent cadaver studies. Numerous studies in the murine model have helped to better understand the molecular signals that govern eyelid embryogenesis. The authors summarize the current findings in molecular biology, and highlight the most significant studies in mice regarding the multiple and interacting signaling pathways involved in regulating normal eyelid morphogenesis.
resultsEyelid morphogenesis involves a succession of subtle yet strictly regulated morphogenetic episodes of tissue folding, proliferation, contraction, and even migration, which may occur simultaneously or in succession.
conclusionsUnderstanding the extraordinary process of building eyelid tissue in embryonic life, and deciphering its underlying signaling machinery has far reaching clinical implications beyond understanding the developmental abnormalities involving the eyelids, and may pave the way for achieving scar-reducing therapies in adult mammalian wounds, or control the spread of malignancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.