Evidence map›Paper›PMID 27124363›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2016

Male Partner Participation in Antenatal Clinic Services is Associated With Improved HIV-Free Survival Among Infants in Nairobi, Kenya: A Prospective Cohort Study.

Adam R Aluisio, Rose Bosire, Betz Bourke, Ann Gatuguta, James N Kiarie, Ruth Nduati, Grace John-Stewart, Carey Farquhar

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In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Adam R Aluisio*Department of Emergency Medicine, Warren Alpert School of Medicine, Brown University, Providence, RI; †Centre for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya; ‡Department of Epidemiology, University of Washington, Seattle, WA; §School of Public Health, Kenyatta University, Nairobi, Kenya; ‖Department of Obstetrics & Gynecology, Kenyatta National Hospital, Nairobi, Kenya; ¶Department of Obstetrics & Gynecology, University of Nairobi, Nairobi, Kenya; **Department of Global Health, University of Washington, Seattle, WA; ††Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya; and ‡‡Department of Medicine, University of Washington, Seattle, WA.
Rose Bosire
Betz Bourke
Ann Gatuguta
James N Kiarie
Ruth Nduati
Grace John-Stewart
Carey Farquhar
University of Washington · USBrown University · USKenya Medical Research Institute · KEKenyatta National Hospital · KEKenyatta University · KEUniversity of Nairobi · KE

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
Impact of counseling on breastfeeding practice and infant HIV-1 transmissionR01TW007629 · FIC · KENYA MEDICAL RESEARCH INSTITUTE (KEMRI) · PI BOSIRE, ROSE KERUBO OTISO · 2007 to 2011
$253k
FIC NIH HHS R01 TW007629FIC NIH HHS R24 TW007988NIAID NIH HHS K24 AI087399NICHD NIH HHS K24 HD054314
6 · The paper itself

Abstract

objectiveThis prospective study investigated the relationship between male antenatal clinic (ANC) involvement and infant HIV-free survival.

methodsFrom 2009 to 2013, HIV-infected pregnant women were enrolled from 6 ANCs in Nairobi, Kenya and followed with their infants until 6 weeks postpartum. Male partners were encouraged to attend antenatally through invitation letters. Men who failed to attend had questionnaires sent for self-completion postnatally. Multivariate regression was used to identify correlates of male attendance. The role of male involvement in infant outcomes of HIV infection, mortality, and HIV-free survival was examined.

resultsAmong 830 enrolled women, 519 (62.5%) consented to male participation and 136 (26.2%) men attended the ANC. For the 383 (73.8%) women whose partners failed to attend, 63 (16.4%) were surveyed through outreach. In multivariate analysis, male report of previous HIV testing was associated with maternal ANC attendance (adjusted odds ratio = 3.7; 95% CI: 1.5 to 8.9, P = 0.003). Thirty-five (6.6%) of 501 infants acquired HIV or died by 6 weeks of life. HIV-free survival was significantly greater among infants born to women with partner attendance (97.7%) than those without (91.3%) (P = 0.01). Infants lacking male ANC engagement had an approximately 4-fold higher risk of death or infection compared with those born to women with partner attendance (HR = 3.95, 95% CI: 1.21 to 12.89, P = 0.023). Adjusting for antiretroviral use, the risk of death or infection remained significantly greater for infants born to mothers without male participation (adjusted hazards ratio = 3.79, 95% CI: 1.15 to 12.42, P = 0.028).

conclusionsMale ANC attendance was associated with improved infant HIV-free survival. Promotion of male HIV testing and engagement in ANC/prevention of mother-to-child transmission services may improve infant outcomes.

Indexed as

Survival RateFemaleHIV InfectionsHumansInfantKenyaMalePregnancyProspective Studies

Identifiers

PMID27124363
PMCPMC5023460
OpenAlexW2344781807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.