SynthesisBritish journal of cancer2016
Meta-analysis of breast cancer mortality benefit and overdiagnosis adjusted for adherence: improving information on the effects of attending screening mammography.
Synthesis in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The screening value of mammography for breast cancer: an overview of 28 systematic reviews with evidence mapping.Journal of cancer research and clinical oncology · 2025Pooled it
- Pooled it
- Informing Women About Overdetection in Breast Cancer Screening: Two-Year Outcomes From a Randomized Trial.Journal of the National Cancer Institute · 2021Trial
- Trial
- Breast Cancer Screening After Gender-Affirming Chest Masculinization Surgery: The Overlooked Role of Mammography.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- Associations of multiple evidence-based care strategies with disease mortality, life expectancy, and disparities in the United States.Health affairs scholar · 2026Article
- Reproduction history and health-promoting behaviors are associated with successful aging and survival.GeroScience · 2026Article
- Circulating tumor cells (CTCs) enumeration and machine-learning based diagnostic biomarkers for breast cancer detection.BMC cancer · 2026Article
- Surrogate endpoint metaregression: useful statistics for regulators and trialists.Journal of clinical epidemiology · 2024Article
- Overdiagnosis Due to Screening Mammography for Breast Cancer among Women Aged 40 Years and Over: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2023Review
- Mortality risks among blue- and white-collar workers: A time series study among Japanese men aged 25-64 years from 1980 to 2015.Journal of occupational health · 2021Article
- Breast Cancer Screening Trends among Lower Income Women of New York: A Time-Series Evaluation of a Population-Based Intervention.European journal of breast health · 2020Article
- An exploration for quantification of overdiagnosis and its effect for breast cancer screening.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Can mammogram readers swiftly and effectively learn to interpret first post-contrast acquisition subtracted (FAST) MRI, a type of abbreviated breast MRI?: a single centre data-interpretation study.The British journal of radiology · 2019Article
- Mortality of women with ductal carcinoma in situ of the breast: a population-based study from the Girona province, Spain (1994-2013).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Observational
- Double Discourse: Qualitative Perspectives on Breast Screening Participation among Obese Women and Their Health Care Providers.International journal of environmental research and public health · 2019Article
- Use of Mastectomy for Overdiagnosed Breast Cancer in the United States: Analysis of the SEER 9 Cancer Registries.Journal of cancer epidemiology · 2019Article
- Occupational inequalities in female cancer incidence in Japan: Hospital-based matched case-control study with occupational class.SSM - population health · 2018Article
- Editorial: Challenges in Quantifying Overdiagnosis.Journal of the National Cancer Institute · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen require information about the impact of regularly attending screening mammography on breast cancer mortality and overdiagnosis to make informed decisions. To provide this information we aimed to meta-analyse randomised controlled trials adjusted for adherence to the trial protocol.
methodsNine screening mammography trials used in the Independent UK Breast Screening Report were selected. Extending an existing approach to adjust intention-to-treat (ITT) estimates for less than 100% adherence rates, we conducted a random-effects meta-analysis. This produced a combined deattenuated prevented fraction and a combined deattenuated percentage risk of overdiagnosis.
resultsIn women aged 39-75 years invited to screen, the prevented fraction of breast cancer mortality at 13-year follow-up was 0.22 (95% CI 0.15-0.28) and it increased to 0.30 (95% CI 0.18-0.42) with deattenuation. In women aged 40-69 years invited to screen, the ITT percentage risk of overdiagnosis during the screening period was 19.0% (95% CI 15.2-22.7%), deattenuation increased this to 29.7% (95% CI 17.8-41.5%).
conclusionsAdjustment for nonadherence increased the size of the mortality benefit and risk of overdiagnosis by up to 50%. These estimates are more appropriate when developing quantitative information to support individual decisions about attending screening mammography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.