ArticleInvestigative ophthalmology & visual science2016
A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract.Communications biology · 2020Pooled it
- Global, regional, national differences and gender disparity in the burden of cataract: current trends and future projections.Eye (London, England) · 2026Article
- Oxidative Stress in Genetic Cataract Formation.Antioxidants (Basel, Switzerland) · 2024Review
- Through theGenes · 2024Review
- Association of age at diagnosis of diabetes with subsequent risk of age-related ocular diseases and vision acuity.World journal of diabetes · 2024Article
- Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions.Journal of the American Heart Association · 2023Article
- The Association between the Differential Expression of lncRNA and Type 2 Diabetes Mellitus in People with Hypertriglyceridemia.International journal of molecular sciences · 2023Article
- DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring.Clinical epigenetics · 2022Article
- Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation.Epigenetics & chromatin · 2022Article
- Exosomal miR-29b found in aqueous humour mediates calcium signaling in diabetic patients with cataract.International journal of ophthalmology · 2021Article
- Common genetic variants have associations with human cortical brain regions and risk of schizophrenia.Genetic epidemiology · 2019Article
- Aqueous humor metabolomic profiles in association with diabetic mellitus.International journal of clinical and experimental pathology · 2018Article
Corrections and comments
- Erratum issuedErratum.2017
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeDiabetic cataract is one of the major eye complications of diabetes. It was reported that cataract occurs two to five times more frequently in patients with diabetes compared with those with no diabetes. The purpose of this study was to identify genetic contributors of diabetic cataract based on a genome-wide association approach using a well-defined Scottish diabetic cohort.
methodsWe adapted linked e-health records to define diabetic cataract. A diabetic cataract case in this study was defined as a type 2 diabetic patient who has ever been recorded in the linked e-health records to have cataracts in both eyes or who had previous cataract extraction surgeries in at least one eye. A control in this study was defined as a type 2 diabetic individual who has never been diagnosed as cataract in the linked e-health records and had no history of cataract surgeries. A standard genome-wide association approach was applied.
resultsOverall, we have 2341 diabetic cataract cases and 2878 controls in the genetics of diabetes audit and research in Tayside Scotland (GoDARTS) dataset. We found that the P value of rs2283290 in the CACNA1C gene was 8.81 × 10(-10), which has reached genome-wide significance. We also identified that the blood calcium level was statistically different between diabetic cataract cases and controls.
conclusionsWe identified supporting evidence that CACNA1C gene is associated with diabetic cataract. The role of calcium in the cataractogenesis needs to be reevaluated in future studies.
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Registered trials
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