Evidence map›Paper›PMID 27124184›Full record

ArticlePloS one2016

Association of Baseline Depressive Symptoms with Prevalent and Incident Pre-Hypertension and Hypertension in Postmenopausal Hispanic Women: Results from the Women's Health Initiative.

Ruth E Zambrana, Lenny López, Gniesha Y Dinwiddie, Roberta M Ray, Charles B Eaton, Lawrence S Phillips, Sylvia Wassertheil-Smoller

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000611 (Women's Health Initiative), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000611 phase3completednot on this map

Women's Health Initiative (WHI)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)ConditionsBone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic NeoplasmsArmshormone replacement therapy, estrogens, progestins, estrogen replacement therapy, diet, fat-restricted
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Ruth E ZambranaDepartment of Women's Studies, Consortium on Race, Gender and Ethnicity, University of Maryland, College Park, Maryland, United States of America.
Lenny LópezDivision of Hospital Medicine, University of California, San Francisco, California, United States of America.
Gniesha Y DinwiddieAfrican American Studies Department, University of Maryland, College Park, Maryland, United States of America.
Roberta M RayFred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Charles B EatonFamily Medicine & Epidemiology, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America.
Lawrence S PhillipsDivision of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Sylvia Wassertheil-SmollerDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
University of Maryland, College Park · USAlbert Einstein College of Medicine · USBrown University · USEmory University · USFred Hutch Cancer Center · USUniversity of California, San Francisco · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shuibing Chen · 2015 to 2026
$27.7M
Association of Acculturation with Type 2 Diabetes Risk Among US LatinosK23DK098280 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOPEZ, LENNY · 2013 to 2016
$737k
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS K23 DK098280NIDDK NIH HHS P30 DK020541WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundDepression and depressive symptoms are risk factors for hypertension (HTN) and cardiovascular disease (CVD). Hispanic women have higher rates of depressive symptoms compared to other racial/ethnic groups yet few studies have investigated its association with incident prehypertension and hypertension among postmenopausal Hispanic women. This study aims to assess if an association exists between baseline depression and incident hypertension at 3 years follow-up among postmenopausal Hispanic women.

methodsProspective cohort study, Women's Health Initiative (WHI), included 4,680 Hispanic women who participated in the observational and clinical trial studies at baseline and at third-year follow-up. Baseline current depressive symptoms and past depression history were measured as well as important correlates of depression-social support, optimism, life events and caregiving. Multinomial logistic regression was used to estimate prevalent and incident prehypertension and hypertension in relation to depressive symptoms.

resultsPrevalence of current baseline depression ranged from 26% to 28% by hypertension category and education moderated these rates. In age-adjusted models, women with depression were more likely to be hypertensive (OR = 1.25; 95% CI 1.04-1.51), although results were attenuated when adjusting for covariates. Depression at baseline in normotensive Hispanic women was associated with incident hypertension at year 3 follow-up (OR = 1.74; 95% CI 1.10-2.74) after adjustment for insurance and behavioral factors. However, further adjustment for clinical covariates attenuated the association. Analyses of psychosocial variables correlated with depression but did not alter findings. Low rates of antidepressant medication usage were also reported.

conclusionsIn the largest longitudinal study to date of older Hispanic women which included physiologic, behavioral and psychosocial moderators of depression, there was no association between baseline depressive symptoms and prevalent nor incident pre-hypertension and hypertension. We found low rates of antidepressant medication usage among Hispanic women suggesting a possible point for clinical intervention.

trial registrationClinicaltrials.gov NCT00000611.

Indexed as

AgedAntidepressive AgentsDepressionDepressive DisorderEthnicityFollow-Up StudiesHispanic or LatinoHumansHypertensionLogistic ModelsLongitudinal StudiesMiddle AgedPostmenopausePrehypertensionPrevalenceProspective StudiesAntidepressive Agents

Identifiers

PMID27124184
PMCPMC4849764
OpenAlexW2344138848

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.